Results 111 to 120 of about 4,318,091 (252)

Orthotopic liver transplantation for primary sclerosing cholangitis [PDF]

, 1988
The incidence or diagnostic rate of sclerosing cholangitis is increasing. Because of the lack of effective medical or surgical therapy for patients with end-stage liver disease and sclerosing cholangitis, results with orthotopic liver transplantation ...
Todo, S, Tzakis, A, Gordon, RD, Makowka, L, Iwatsuki, S, Miller, C, Starzl, TE, Van Thiel, D, Esquivel, CO, Marsh, JW   +9 more
core   +1 more source

Rare Variants in PFIC‐Related Genes Among Adults With Intrahepatic Cholestasis

Hepatology Research, EarlyView.
ABSTRACT Aim Biallelic pathogenic variants in progressive familial intrahepatic cholestasis (PFIC)‐related genes cause severe pediatric cholestasis. However, the clinical significance of heterozygous variants in adult intrahepatic cholestasis remains unclear.
Shunji Hirose, Kota Tsuruya, Yusuke Mishima, Yoshitaka Arase, Koichi Shiraishi, Vu Thi Hao, Satsuki Ieda, Masayuki Tanaka, Sanae Isaki, Tatehiro Kagawa   +9 more
wiley   +1 more source

Pemafibrate Improves Cholestatic Markers Regardless of the Presence of Primary Biliary Cholangitis

Hepatology Research, EarlyView.
Pemafibrate improves liver function markers related to bile flow in primary biliary cholangitis (PBC), but whether this effect is disease‐specific remains unclear. In this study, pemafibrate reduced these markers in patients with and without PBC, suggesting broader effects on bile flow beyond PBC.
Ryohei Tanigawa, Yoshiyuki Ueno, Hirokazu Takahashi, Ayumi Saito, Hideki Suganami, Atsushi Tanaka   +5 more
wiley   +1 more source

Histological AI‐Assisted Analysis Outperforms Pathologist Assessment in Predicting Disease Outcomes in PSC Patients

Hepatology Research, EarlyView.
Analyzing liver histology with AI assistance demonstrates superior prognostic performance compared to manual scoring in PSC. AI‐measured portal inflammation, fibrosis, biliary epithelium, and blood vessels predicted key clinical endpoints, such as liver transplantation due to end‐stage liver disease, highlighting the importance of liver histology as a ...
Anna M. Salonen, Iiris Nyholm, Linn Tähti, Matilda Sinkko, Darshan Kumar, Martti Färkkilä, Johanna Arola, Mikko P. Pakarinen, Sonja Boyd, Nelli Sjöblom   +9 more
wiley   +1 more source

Indoleamine 2,3‐Dioxygenase 1 as an Adjunctive Histopathological Marker of Cholangitis Activity in Primary Biliary Cholangitis

Hepatology Research, EarlyView.
IDO‐1 immunostaining identifies primary biliary cholangitis even in morphologically subtle bile duct lesions. IDO‐1 expression reflects cholangitis activity and is suppressed by ursodeoxycholic acid treatment, indicating its value as a dynamic diagnostic adjunct rather than a static marker of chronic damage.
Kaori Yoshimura, Shinji Shimoda, Ryoka Masuda, Tram Nguyen Thi, Rui Yang, Quynh Nguyen Thi, Dong Le Thanh, Yuko Tamano, Yasunori Sato, Taro Yamashita, Kenichi Harada   +10 more
wiley   +1 more source

Dye-based chromoendoscopy detects more neoplasia than white light endoscopy in patients with primary sclerosing cholangitis and IBD

Endoscopy International Open
Background and study aims Patients with primary sclerosing cholangitis and inflammatory bowel disease (IBD) have a high risk of colorectal cancer.
Rodrigo V Motta, Vipin Gupta, Karen Hartery, Paul Bassett, Simon J Leedham, Roger W Chapman, Simon PL Travis, Emma L Culver, James E. East   +8 more
doaj   +1 more source

Validation of the Baveno Endoscopy Avoidance Criteria in Japanese Patients With Chronic Liver Disease: A Real‐World Cohort Study

Hepatology Research, EarlyView.
Many patients with chronic liver disease can safely avoid unnecessary screening endoscopy using the Baveno VII criteria. We developed a simple three‐factor score to identify patients at high risk of serious esophageal varices. Using both approaches together may improve the efficiency and safety of endoscopic screening.
Maiko Asami, Yoshihito Uchida, Shohei Tsuji, Satsuki Ando, Kayoko Sugawara, Masamitsu Nakao, Nobuaki Nakayama, Yukinori Imai, Suguru Mizuno, Satoshi Mochida   +9 more
wiley   +1 more source

Psychological Pathways From Disease Activity to Quality of Life in Ulcerative Colitis and Crohn's Disease: A Cross‐Sectional Serial Mediation Study

Journal of Clinical Nursing, EarlyView.
ABSTRACT Aim To examine whether psychological distress and self‐efficacy serially mediate the relationship between disease activity and quality of life in patients with ulcerative colitis and Crohn's disease. Design A cross‐sectional study. Methods We included 525 hospitalized patients with inflammatory bowel disease (224 with ulcerative colitis, 301 ...
Qiuxia Jiang, Alan Liu, Juan Liu, Lili Wu, Qian Zhang, Qing Xu, Li Xie, Yue Yu, Yan Xu   +8 more
wiley   +1 more source

A new paradigm of the pathogenesis of primary sclerosing cholangitis associated with ulcerative colitis: microbiota and system intestine-liver. A review

Терапевтический архив
The close relationship between primary sclerosing cholangitis and ulcerative colitis has given rise to a number of hypotheses aimed at deciphering their pathogenesis from the standpoint of bidirectional connections involving immune, endocrine and ...
Evgenia S. Sbikina, Elena V. Vinnitskaya, Asfold I. Parfenov   +2 more
doaj   +1 more source

Tissue distribution of autoantigen specific for primary sclerosing cholangitis.

, 1993
AIM: To investigate the tissue distribution of the autoantigen specific for primary sclerosing cholangitis. METHODS: A range of normal frozen tissues including nervous system, muscle, uterus, ovary, prostate, pancreas, thyroid, salivary gland, adrenal ...
Fleming, KA, Chapman, RW, Lo, SK
core   +1 more source