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Coexisting Primary Sclerosing Cholangitis and Autoimmune Hepatitis: Overlapping Challenges in Diagnosis and Treatment

Case Reports in Gastroenterology
Introduction: Hepatobiliary overlap syndromes describe the coinciding presentation of more than one immune-mediated biliary and liver disease in a single patient and present complex challenges in diagnosis and treatment.
Hannah W. Fiske +7 more
doaj +1 more source

Autoimmune pancreatitis/IgG4-associated cholangitis and primary sclerosing cholangitis--overlapping or separate diseases?

, 2009
Autoimmune pancreatitis is a recently described fibroinflammatory disease which is characterised by raised serum levels of IgG4 (in >70% of cases), and an IgG4-positive lymphoplasmacytic tissue infiltrate. A favourable and rapid clinical response to oral
Webster, George J.M. +5 more
core +1 more source

The Immunology of Primary Sclerosing Cholangitis

Springer Seminars in Immunopathology, 1990
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease that is characterized by an obliterative inflammatory fibrosis of the biliary tract. This chronic inflammation frequently results in bile duct obliteration, biliary cirrhosis, hepatic failure and sometimes in cholangiocarcinoma1.
openaire +2 more sources

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Autoimmune hepatitis is a type of chronic hepatitis that is usually progressive, has unknown etiology, and can occur at any age. In the present case, drug‐associated autoimmune hepatitis (DIAIH) was discussed, and DIAIH secondary to isoniazid (INH) was found in two case reports in the literature.
Murat AY, Erhan Bozkurt
wiley +1 more source

Farnesoid X Receptor Agonists: A Promising Therapeutic Strategy for Gastrointestinal Diseases

Gastro Hep Advances
Farnesoid X receptor (FXR) agonists have emerged as a promising therapeutic strategy for the management of various gastrointestinal (GI) diseases, including primary biliary cholangitis, nonalcoholic fatty liver disease, inflammatory bowel disease ...
Mohammad Almeqdadi, Fredric D. Gordon
doaj +1 more source

Update on primary sclerosing cholangitis

, 2013
Primary sclerosing cholangitis (PSC) remains one of the most challenging conditions of clinical hepatology. There has been a steady growth in research to overcome this fact and the present review aims at summarizing the most recently published literature.
Boberg, Kirsten Muri, Karlsen, Tom Hemming, Karlsen, Tom H. +2 more
core +1 more source

Hepatic Sarcoidosis Unmasked by Chronic Pruritus and Esophageal Varices: A Case Report

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Sarcoidosis is a granulomatous disease that affects multiple organs, commonly the liver, with manifestations from asymptomatic disease to cirrhosis and liver failure. A 43‐year‐old male presented with generalized pruritus. Liver biopsy demonstrated findings consistent with sarcoidosis, and treatment was initiated. We emphasize timely follow‐up
Ming Zheng, Keroles Saadalla, Sandipa Sharma +2 more
wiley +1 more source

Building a Robust Investigator‐Initiated Platform: The I‐CARE Experience

Clinical Pharmacology &Therapeutics, Volume 119, Issue 6, Page 1537-1546, June 2026.
Investigator‐initiated studies that include information collected by patients are rising, but limited data is available on patient and investigator experience in this setting. The I‐CARE cohort included patients with inflammatory bowel disease (IBD) monthly collecting clinical information in 15 countries for up to 6 years.
Julien Kirchgesner +906 more
wiley +1 more source

Association Between Dietary Patterns and Sarcopenia in Patients With Liver Cirrhosis: A Cross‐Sectional Study

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background and Aims Sarcopenia is a prevalent and debilitating complication in patients with liver cirrhosis, contributing to poor clinical outcomes. Although diet quality is believed to influence muscle health, the role of overall dietary patterns in patients with cirrhosis remains inadequately explored.
Elham Sobhrakhshankhah +5 more
wiley +1 more source

N6‐Methyladenosine (m6A) in Liver Disease: Pathogenic Mechanisms and Therapeutic Potential

iNew Medicine, Volume 2, Issue 2, June 2026.
ABSTRACT Accumulating evidence highlights the critical role of epigenetic modifications, particularly N6‐methyladenosine (m6A), in liver disease. As the most abundant RNA modification in eukaryotic cells, m6A is dynamically regulated by multicomponent m6A methyltransferases (e.g., METTL3 and METTL14), demethylases (FTO and ALKBH5), and m6A‐binding ...
Yingfen Chen +6 more
wiley +1 more source

gastroenterology
diseases of the digestive system
cholangitis

ulcerative colitis
psc
inflammatory bowel disease