Results 131 to 140 of about 4,318,091 (252)

Coexisting Primary Sclerosing Cholangitis and Autoimmune Hepatitis: Overlapping Challenges in Diagnosis and Treatment

Case Reports in Gastroenterology
Introduction: Hepatobiliary overlap syndromes describe the coinciding presentation of more than one immune-mediated biliary and liver disease in a single patient and present complex challenges in diagnosis and treatment.
Hannah W. Fiske, Firrah Saeed, Christopher Ward, Boris Sinayuk, Veronica Ulici, Michael Curry, Edward Feller, Samir A. Shah   +7 more
doaj   +1 more source

The Immunology of Primary Sclerosing Cholangitis

Springer Seminars in Immunopathology, 1990
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease that is characterized by an obliterative inflammatory fibrosis of the biliary tract. This chronic inflammation frequently results in bile duct obliteration, biliary cirrhosis, hepatic failure and sometimes in cholangiocarcinoma1.
openaire   +2 more sources

Delayed Argon Plasma Coagulation After Endoscopic Injection Sclerotherapy for Esophageal Varices Reduces Recurrence Risk

DEN Open, Volume 7, Issue 1, April 2027.
ABSTRACT Objectives Argon plasma coagulation (APC) is commonly used as consolidation therapy after endoscopic injection sclerotherapy (EIS) for esophageal varices (EVs); however, the optimal timing of APC remains unclear. This study evaluated the association between the EIS–APC interval and clinical outcomes.
Takumi Yanagita, Takuto Hikichi, Jun Nakamura, Tsunetaka Kato, Minami Hashimoto, Mitsuru Otsuka, Eisuke Kameoka, Rei Suzuki, Mitsuru Sugimoto, Hiroyuki Asama, Hiroshi Shimizu, Kento Osawa, Rei Ohira, Keisuke Kudo, Daiki Nemoto, Masao Kobayakawa, Hiromasa Ohira   +16 more
wiley   +1 more source

Farnesoid X Receptor Agonists: A Promising Therapeutic Strategy for Gastrointestinal Diseases

Gastro Hep Advances
Farnesoid X receptor (FXR) agonists have emerged as a promising therapeutic strategy for the management of various gastrointestinal (GI) diseases, including primary biliary cholangitis, nonalcoholic fatty liver disease, inflammatory bowel disease ...
Mohammad Almeqdadi, Fredric D. Gordon
doaj   +1 more source

Primary sclerosing cholangitis [PDF]

Hepatology, 1999
P, Angulo, K D, Lindor
openaire   +2 more sources

Recent Development of Endo‐hepatology

DEN Open, Volume 7, Issue 1, April 2027.
ABSTRACT Endo‐hepatology is a rapidly evolving field encompassing endoscopic diagnosis and treatment of hepatobiliary diseases, primarily using endoscopic ultrasound (EUS). Since its conceptualization in 2012, the field has expanded dramatically alongside advances in interventional EUS. A landmark 2024 review broadened the concept to include endoscopic
Akira Yamamiya, Atsushi Irisawa, Yasunori Inaba, Rafael Romero‐Castro   +3 more
wiley   +1 more source

The Circulating Cholangiocarcinoma Protein Biomarkers CRP and MASP2 Also Predict Gallbladder Cancer Risk

International Journal of Cancer, Volume 159, Issue 10, Page 2403-2407, 15 November 2026.
ABSTRACT In a recent publication, Lapitz et al. reported differences in serum levels that predict the development of cholangiocarcinoma (CCA) in patients with primary sclerosing cholangitis prior to clinical manifestation. We examined whether these biomarkers also predict the risk of gallbladder cancer (GBC) in European prospective plasma samples from ...
Linda Zollner, Jeroen Krijgsveld, Dominique Scherer, Justo Lorenzo Bermejo, on behalf of the EULAT Eradicate GBC Consortium   +4 more
wiley   +1 more source

Mucosal‐Associated Invariant T Cells in Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
The roles of MAIT cells in health and disease and their therapeutic applications. In healthy individuals, riboflavin metabolites secreted by commensal bacteria at mucosal sites are presented by MR1, leading to the activation of MAIT cells. Activated MAIT cells can maintain the barrier integrity of mucosal tissues in a steady state or migrate to the ...
Yu Zhao, Feng‐Mi Ou, Dan Liang, Yang Gao, Qing‐Qing Li, Yi‐Qun Kuang   +5 more
wiley   +1 more source

Next Generation Sequencing for the Differentiation of Benign and Malignant Biliary Strictures

Liver International, Volume 46, Issue 10, October 2026.
ABSTRACT The differentiation between benign and malignant biliary strictures remains a significant clinical challenge. Recent studies have suggested that next generation sequencing (NGS) can improve the diagnostic accuracy. However, evidence on its performance in routine clinical practice is limited. Therefore, validation of the diagnostic value of NGS
Antonia Gillmeister, Julia Husman, Renate Schmelz, Stefan Brückner, Jochen Hampe, Daniela Aust, Sebastian Zeissig   +6 more
wiley   +1 more source

Primary sclerosing cholangitis: diagnostic and treatment approach [PDF]

Introduction. Primary sclerosing cholangitis (PSC) is a rare liver disease characterized by chronic inflammation and fibrosis causing multifocal biliary strictures, biliary stasis, fibrosis, and liver cirrhosis.
Geevarghese, Mathew
core   +1 more source