Results 141 to 150 of about 37,561 (261)

Farnesoid X Receptor Agonists: A Promising Therapeutic Strategy for Gastrointestinal Diseases

Gastro Hep Advances
Farnesoid X receptor (FXR) agonists have emerged as a promising therapeutic strategy for the management of various gastrointestinal (GI) diseases, including primary biliary cholangitis, nonalcoholic fatty liver disease, inflammatory bowel disease ...
Mohammad Almeqdadi, Fredric D. Gordon
doaj   +1 more source

Diagnostic and Prognostic Values of Bile Biomarkers for Malignant Biliary Stenosis

Liver International, Volume 46, Issue 5, May 2026.
ABSTRACT Introduction Differentiating between malignant and benign biliary strictures remains a clinical challenge because current diagnostic tools have limited sensitivity. The detection of tumour‐related biomarkers directly in bile, which is in close contact with the lesion, may enhance diagnostic accuracy.
E. Gigante, V. Untereiner, S. Caruso, R. Rhaiem, L. Grados, C. Boulagnon‐Rombi, S. Adam, G. D. Sockalingum, R. Garnotel, G. Thiefin   +9 more
wiley   +1 more source

Albumin Restores Endothelial Cell Mitochondrial Morphology in Patients With Decompensated Cirrhosis

Liver International, Volume 46, Issue 5, May 2026.
ABSTRACT Background & Aims Endothelial cell (EC) activation is a critical driver of disease progression in cirrhosis, contributing to acute decompensation (AD) and acute‐on‐chronic liver failure (ACLF). Although human albumin administration improves EC function in cirrhotic patients with hypoalbuminemia, its direct effects on ECs remain unclear.
Susan E. Fischer, Rudmer J. Postma, Roel Bijkerk, Annarein J. C. Kerbert, Anton Jan van Zonneveld, Minneke J. Coenraad   +5 more
wiley   +1 more source

A Case Study and Review of the Literature on IgA Nephropathy in Crohn's Disease

Clinical Case Reports, Volume 14, Issue 4, April 2026.
ABSTRACT IgA nephropathy (IgAN) is the most frequently reported glomerular disease associated with inflammatory bowel disease (IBD), particularly Crohn's disease (CD), although pediatric cases remain rare. We report IgAN in a 16‐year‐old male with CD following intestinal surgery and during long‐term infliximab therapy, with renal impairment occurring ...
Giovanna Fernanda Vazzana, Alessia Romano, Chiara Casuscelli, Alberto La Spada, Domenico Santoro, Roberto Chimenz, Claudio Romano   +6 more
wiley   +1 more source

Dilation Device Use and Concomitant Antegrade Stenting are Associated With Procedure‐related Early Adverse Events After Endoscopic Ultrasound‐guided Hepaticogastrostomy: A Retrospective Multicenter Study

DEN Open, Volume 6, Issue 1, April 2026.
This multicenter study identified use of dilation devices and antegrade stenting are risk factors for procedure‐related early adverse events following endoscopic ultrasound‐guided hepaticogastrostomy. ABSTRACT Objectives Endoscopic ultrasound‐guided hepaticogastrostomy (EUS‐HGS) is useful in cases of endoscopic retrograde cholangiopancreatography ...
Shinichi Hashimoto, Hiroki Taguchi, Norimasa Araki, Yu Yamazato, Hiroki Iwata, Yuji Tabira, Ryusuke Shibata, Yusuke Kamikihara, Koshiro Toyodome, Issei Kojima, Takafumi Hamada, Kengo Tsuneyoshi, Yoshitaka Nakamura, Hiroki Yano, Makoto Hinokuchi, Shiho Arima, Shiroh Tanoue, Fumisato Sasaki, Shuji Kanmura, Akio Ido   +19 more
wiley   +1 more source

Distal Bile Duct Metastasis From Rectal Cancer: The Diagnostic Contribution of Intraductal Ultrasonography

DEN Open, Volume 6, Issue 1, April 2026.
ABSTRACT A 49‐year‐old male developed liver dysfunction during chemotherapy for rectal cancer located in the rectosigmoid region. Although magnetic resonance cholangiopancreatography initially indicated sclerosing cholangitis, endoscopic retrograde cholangiopancreatography and intraductal ultrasonography revealed multiple non‐contiguous intraductal ...
Shinji Monoe, Ryo Nishio, Arihiro Nakano, Yu Yasue, Takahiro Yamashita, Hitoshi Iwata   +5 more
wiley   +1 more source

A Clinical Scoring Model to Predict Post‐Endoscopic Retrograde Cholangiopancreatography Pancreatitis in Biliary Endoscopic Retrograde Cholangiopancreatography for Patients With Intact Papilla: A Large Multicenter Prospective Cohort Study

DEN Open, Volume 6, Issue 1, April 2026.
ABSTRACT Objectives The risk of post‐endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) needs to be predicted in order to take adequate preventive measures in individual cases. The aim of this study was to develop a clinical prediction rule for PEP in biliary ERCP for patients with intact papilla.
Koichi Fujita, Shujiro Yazumi, Hisakazu Matsumoto, Masanori Asada, Hiroko Nebiki, Keiji Hanada, Kazuya Matsumoto, Toru Maruo, Mamoru Takenaka, Hideki Kamada, Chishio Noguchi, Hidefumi Nishikiori, Toshifumi Doi, Teru Kumagi, Takao Iemoto, Nobuaki Azemoto, Takashi Kawamura, Hirofumi Kawamoto, for the Bilio‐pancreatic Study Group of West Japan   +18 more
wiley   +1 more source

A Rare Case of Obstructive Jaundice Secondary to Hemobilia Post Endoscopic Ultrasound Guided Liver Biopsy

DEN Open, Volume 6, Issue 1, April 2026.
ABSTRACT Hemobilia is an uncommon complication of endoscopic liver biopsy (LB), rarely resulting in clinically significant biliary obstruction. We describe the second reported case of hemobilia‐induced obstructive jaundice secondary to endoscopic ultrasound‐guided LB (EUS‐LB).
Dhruv Patel, Anas Khouri, Ali Totonchian, Asad Ur Rahman   +3 more
wiley   +1 more source

Advances in Crohn's Disease: A Comprehensive Review of Pathophysiology, Diagnosis, and Emerging Therapeutics

JGH Open, Volume 10, Issue 4, April 2026.
ABSTRACT Crohn's disease (CD) is a chronic inflammatory condition of the bowel with a rising global incidence. Its complex etiology involves genetic susceptibility, environmental factors, and alterations in the gut microbiota, leading to dysregulated immune responses.
Yoon‐Kyo An, Robert Gilmore, Graham Radford‐Smith, Jakob Begun   +3 more
wiley   +1 more source

Multicenter Validation Study of the Clinical Diagnostic Criteria for IgG4‐Related Sclerosing Cholangitis 2020 in Japan

Journal of Hepato-Biliary-Pancreatic Sciences, Volume 33, Issue 4, Page 294-303, April 2026.
In this Japanese multicenter validation study, Naitoh and colleagues analyzed clinical data from 1034 patients with IgG4‐related sclerosing cholangitis to evaluate the 2020 clinical diagnostic criteria. The IgG4‐SC2020 criteria demonstrated higher sensitivity than the 2012 criteria while maintaining high specificity, and reclassified cases not ...
Itaru Naitoh, Takahiro Nakazawa, Kensuke Kubota, Takayoshi Nishino, Akira Nakamura, Dai Inoue, Takanori Sano, Kazuhiro Kikuta, Yusuke Kurita, Kazuro Chiba, Tsukasa Ikeura, Hiroyuki Matsubayashi, Takuya Ishikawa, Masaki Kuwatani, Terumi Kamisawa, Ichiro Yasuda, Mitsuhiro Kawano, Atsushi Masamune, Japan Pancreatitis Study Group, Yoko Abe, Atsushi Irisawa, Hiroyuki Tanaka, Eizaburo Ohno, Tatsuru Maruo, Toshiharu Ueki, Rei Suzuki, Tadayuki Takagi, Hiromasa Ohira, Shirou Tanoue, Akio Ido, Takahiro Komori, Kayashima Atsuo, Masayasu Horibe, Eisuke Iwasaki, Masahiro Tsujimae, Yuzo Kodama, Kazushige Uchida, Masayuki Ueno, Kenji Notohara, Shotaro Kakehashi, Nao Fujimori, Eiji Nakatani, Yasuki Hori, Michihiro Yoshida, Hiroki Kawashima, Kazunao Hayashi, Shuji Terai, Kosaku Morimoto, Ryosuke Sato, Kazuyuki Matsumoto, Hironari Kato, Yoshiharu Masaki, Hiroshi Nakase, Toshihiko Arizumi, Atsushi Tanaka, Ryotaro Matusmoto, Tetsuya Takikawa, Ryosuke Tonozuka, Takao Itoi, Kenji Hirano, Nobuhiko Hayashi   +60 more
wiley   +1 more source