Results 121 to 130 of about 37,561 (261)

Intrahepatic Cholangiocarcinoma: Epidemiological Trends, Risk Factors, Diagnostic Challenges, and Advances in Personalized Therapy—A Comprehensive Review

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Intrahepatic cholangiocarcinoma (iCCA) ranks as the second most common primary liver cancer, compared to about 20% of cases. Its global incidence has climbed over the past four decades, yet early detection remains indefinable due to its asymptomatic nature. Five‐year survival rate of approximately is under 10%.
Yaqoob Muhammad, YuZhu Jin, Kai Luo, He Bai, Xudong Zhang, Xu Sun, Zahoor Maheen, Ali Tanveer, Saeed Muddasar Muhammad, Jialin Qu, Guixin Zhang   +10 more
wiley   +1 more source

Primary Sclerosing Cholangitis from Childhood to Adult Age : Risk Factors, Monitoring and Outcome [PDF]

, 2017
BACKGROUND AND AIM This thesis includes two studies conducted in a paediatric and two studies conducted in an adult primary sclerosing cholangitis (PSC) population.
Tenca, Andrea
core  

Microscopic colitis and primary sclerosing cholangitis are bidirectionally associated: A nationwide matched cohort and case–control study

Journal of Internal Medicine, EarlyView.
Abstract Background Microscopic colitis (MC) is an inflammatory disease of the colon. Although there is a known association between inflammatory bowel disease (IBD) and primary sclerosing cholangitis (PSC), evidence linking MC and PSC remains scarce. We aimed to investigate the bidirectional association between MC and PSC.
David Bergman, Anders Forss, Jiangwei Sun, Fahim Ebrahimi, Björn Lindkvist, Charlotte Hedin, Hannes Hagström, Annika Bergquist, Jialu Yao, Jonas F. Ludvigsson   +9 more
wiley   +1 more source

Association Between Oral Lichen Planus and Non‐Oral Cancers: A Multicentre Case–Control SIPMO Study

Oral Diseases, EarlyView.
ABSTRACT Objectives This multicentre case–control study aimed to investigate the potential association between oral lichen planus (OLP) and extraoral cancers. The secondary objective included the identification of risk factors for this association. Methods The study was conducted between January 2023 and June 2024 and included 21 Italian Oral Medicine ...
Gioele Gioco, Anna Schiavelli, Alessandra Majorana, Elena Bardellini, Silvio Abati, Andrea Sardella, Francesco Spadari, Matteo Pellegrini, Dorina Lauritano, Raffaele Borgia, Monica Pentenero, Samuele Sutera, Paolo Giacomo Arduino, Alessio Gambino, Roberto Broccoletti, Matteo Biasotto, Giulia Ottaviani, Lorenzo Azzi, Alessandro D'Aiuto, Davide Bartolomeo Gissi, Andrea Gabusi, Andrea Santarelli, Marco Mascitti, Paolo Vescovi, Gloria Bortolotti, Maddalena Manfredi, Marco Meleti, Grazia Zino, Umberto Romeo, Gianluca Tenore, Gianfranco Favia, Luisa Limongelli, Massimo Petruzzi, Francesca Dimilito, Lorenzo Lo Muzio, Maria Eleonora Bizzoca, Giuseppina Campisi, Vera Panzarella, Stefania Leuci, Rosario Serpico, Alberta Lucchese, Giuseppe Colella, Giacomo Oteri, Antonia Marcianò, Gaetano Isola, Alessandro Polizzi, Amerigo Giudice, Elena Calabria, Umberto Mariani, Daniela Adamo, Federica Canfora, Filippo Graziani, Marco Nisi, Michele Giuliani, Luisa Ritrovato, Federica De Micheli, Cosimo Rupe, Francesco Scilla, Romeo Patini, Massimo Cordaro, Michele Davide Mignogna, Carlo Lajolo, SIPMO (Italian Society of Oral Pathology and Medicine)   +62 more
wiley   +1 more source

Dye-based chromoendoscopy detects more neoplasia than white light endoscopy in patients with primary sclerosing cholangitis and IBD

Endoscopy International Open
Background and study aims Patients with primary sclerosing cholangitis and inflammatory bowel disease (IBD) have a high risk of colorectal cancer.
Rodrigo V Motta, Vipin Gupta, Karen Hartery, Paul Bassett, Simon J Leedham, Roger W Chapman, Simon PL Travis, Emma L Culver, James E. East   +8 more
doaj   +1 more source

The role of neutrophils in the pathophysiology of inflammatory bowel diseases

Periodontology 2000, EarlyView.
Abstract Objectives Inflammatory bowel disease (IBD) encompasses a spectrum of chronic disorders of the gastrointestinal tract, with a potential bidirectional relationship with periodontitis. Neutrophils are key regulators of immune‐inflammatory responses and play a major role in both diseases.
Joao Paulo Steffens, Ekin Yay‐Kus, Rafael Scaf de Molon, Viorelia Stoica, Peter Rimmer, Josefine Hirschfeld, Asif Jilani Iqbal, Tariq Iqbal, Iain Chapple   +8 more
wiley   +1 more source

Systemic Drivers and Molecular Mechanisms of Sarcopenia in Aetiology‐Specific End‐Stage Liver Disease

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 3, June 2026.
ABSTRACT Background Patients with end‐stage liver disease (ESLD) often present with sarcopenia, defined as loss of skeletal muscle mass and quality, which is associated with reduced quality of life and increased mortality. However, the molecular mechanisms driving sarcopenia in ESLD are not fully understood and there are currently no therapeutic ...
Thomas Nicholson, Sophie L. Allen, Jonathan I. Quinlan, Amritpal Dhaliwal, Michael Macleod, Joshua Price, Jon Hazeldine, Michael S. Sagmeister, Caitlin Ditchfield, Kirsty C. McGee, Felicity R. Williams, Ahmed M. Elsharkawy, Matthew J. Armstrong, Carolyn A. Greig, Janet M. Lord, Leigh Breen, Simon W. Jones   +16 more
wiley   +1 more source

A new paradigm of the pathogenesis of primary sclerosing cholangitis associated with ulcerative colitis: microbiota and system intestine-liver. A review

Терапевтический архив
The close relationship between primary sclerosing cholangitis and ulcerative colitis has given rise to a number of hypotheses aimed at deciphering their pathogenesis from the standpoint of bidirectional connections involving immune, endocrine and ...
Evgenia S. Sbikina, Elena V. Vinnitskaya, Asfold I. Parfenov   +2 more
doaj   +1 more source

Molecular Quantification of Fibrogenesis and Macrophage Activation Associate With Clinical Worsening in Patients With Cirrhosis

Liver International Communications, Volume 7, Issue 2, June 2026.
ABSTRACT Knowledge of the potential of biomarkers for monitoring clinical improvement, assessing trajectory or disease progression in advanced chronic liver disease is still insufficient. This study investigated biomarkers of fibrosis and macrophage activation over time in newly diagnosed patients with cirrhosis and their potential association with ...
Emilie Toft Skovgaard, Jens Peter Goetze, Thit Mynster Kronborg, Søren Møller, Henning Grønbæk, Holger Jon Møller, Morten Karsdal, Diana Julie Leeming, Nina Kimer   +8 more
wiley   +1 more source

Abcb4 Haploinsufficiency Sensitises Mice to a Diet‐Induced PSC‐Like Hepatobiliary Phenotype With Gallstone Formation

Liver International Communications, Volume 7, Issue 2, June 2026.
ABSTRACT ABCB4 translocates phospholipids (PL) into bile to buffer the toxicity of bile acids (BA) and free cholesterol (CHOL). While recessively inherited ABCB4 deficiency causes childhood Progressive Familial Intrahepatic Cholestasis type 3, haploinsufficiency has been linked to adult‐onset hepatobiliary diseases.
Eric L. Bell, Youhwa Jo, Jennifer K. Truong, Nathan O. Fuller, John P. Miller, Alastair S. Garfield, Robert O. Hughes   +6 more
wiley   +1 more source