Results 121 to 130 of about 27,193 (247)

A new paradigm of the pathogenesis of primary sclerosing cholangitis associated with ulcerative colitis: microbiota and system intestine-liver. A review

open access: yesТерапевтический архив
The close relationship between primary sclerosing cholangitis and ulcerative colitis has given rise to a number of hypotheses aimed at deciphering their pathogenesis from the standpoint of bidirectional connections involving immune, endocrine and ...
Evgenia S. Sbikina   +2 more
doaj   +1 more source

Elevated trimethylamine-N-oxide (TMAO) is associated with poor prognosis in primary sclerosing cholangitis patients with normal liver function

open access: yes, 2016
Background Trimethylamine-N-oxide (TMAO) is produced in the liver from trimethylamine, which is exclusively generated by gut bacteria. Objective The objective of this article is to investigate the relationship between TMAO and primary sclerosing ...
Boberg, Kirsten Muri   +9 more
core   +1 more source

Pre‐TIPS Liver and Spleen Volumetry Are Not Associated With Liver‐Related Outcomes After TIPS Placement for Refractory Ascites

open access: yesLiver International, Volume 46, Issue 7, July 2026.
ABSTRACT Background & Aims Transjugular intrahepatic portosystemic shunt (TIPS) improves survival in refractory ascites. A careful patient's selection is mandatory as TIPS can lead to complications. Liver volumetry is predictive of outcomes before hepatic surgery, but data on its role before TIPS placement are scarce. We aimed to evaluate whether liver
José Ursic Bedoya   +16 more
wiley   +1 more source

Reframing Wnt/β‐Catenin Signalling in Liver Fibrosis: Transcriptional State Regulation by CBP and p300

open access: yesLiver International, Volume 46, Issue 7, July 2026.
ABSTRACT Liver fibrosis is a shared pathological phenotype of chronic liver diseases of diverse etiologies, including viral hepatitis, alcohol‐associated liver disease and metabolic dysfunction–associated steatohepatitis (MASH), as well as cholestatic liver diseases such as primary biliary cholangitis and primary sclerosing cholangitis, and may ...
Kiminori Kimura, Michinori Kohara
wiley   +1 more source

Acute HEV Infection Is a Relevant Cause of Decompensation and ACLF in Patients With Liver Cirrhosis

open access: yesLiver International, Volume 46, Issue 7, July 2026.
ABSTRACT Background and Aims Hepatitis E virus (HEV) infection is very frequent in Europe with more than 2 million annual infections. Patients with liver cirrhosis may face an increased risk of suffering from acute‐on‐chronic liver failure (ACLF) due to HEV infection.
Katja Dinkelborg   +12 more
wiley   +1 more source

Challenges in Diagnosing Intrahepatic Cholangiolithiasis in a 39-Year-Old Patient

open access: yesРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии
Aim: to highlight the challenges of diagnosing and treating a patient with severe intrahepatic cholangiolithiasis.Key points. Primary sclerosing cholangitis is a chronic progressive liver disease characterized by destructive inflammation and fibrosis in ...
A. K. Guseva   +9 more
doaj   +1 more source

Clinical features in primary sclerosing cholangitis

open access: yes, 1998
This article describes clinical features in primary sclerosing cholangitis, including clinical presentation and complications. The natural history of the disease is discussed, as well as the strong association to inflammatory bowel ...
Broomé, U, Bergquist, A,
core   +1 more source

Outcomes of Liver Transplant Versus Partial Hepatectomy for Perihilar Cholangiocarcinoma Patients Requiring Arterial Reconstruction

open access: yesLiver International, Volume 46, Issue 7, July 2026.
ABSTRACT Background and Aims Liver resection (LR) and orthotopic liver transplantation (OLT) are therapeutic options for locally advanced perihilar cholangiocarcinoma (pCCA) requiring hepatic artery reconstruction (HAR). This study aimed to compare short‐ and long‐term outcomes of LR and OLT. Outcomes were major vascular complications, 90‐day mortality,
Edoardo Poletto   +52 more
wiley   +1 more source

Acute Upper Gastrointestinal Bleeding is Associated With Poor Prognosis in Patients With Biliary Tract Cancer

open access: yesCancer Medicine, Volume 15, Issue 6, June 2026.
ABSTRACT Aim Upper gastrointestinal bleeding (UGIB) is associated with an unfavorable outcome in cancer patients. In patients with biliary tract cancer (BTC), data on the incidence, management, and prognostic implications of UGIB are limited. This study investigated the prevalence, treatment efficacy, and prognostic factors associated with UGIB in BTC.
Jan Christoph Schumacher   +8 more
wiley   +1 more source

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