Results 41 to 50 of about 217,641 (208)

Upconversion‐Based Remote Deep Brain Modulation for Therapeutic Dissection of Parkinson's Disease

Advanced Therapeutics, EarlyView.
An upconversion‐based wireless optogenetic strategy enables an all‐optical deep brain modulation solution for treating Parkinson's disease in rodent animals without using electronics or any tethered cables, providing experimental evidence supporting a therapeutic mechanism of STN‐DBS by disruption of anterograde signal transmission along the indirect ...
Wenchong Zhang, Xudong Lin, Kai Xie, Zixun Wang, Tianying Sun, Zhen Xu, Haibing Yue, Xi Chen, Qinghai Liao, Ming Liu, Wing Ho Yung, Jufang He, Feng Wang, Peng Shi   +13 more
wiley   +1 more source

Neuroprotective efficacy of P7C3 compounds in primate hippocampus. [PDF]

, 2018
There is a critical need for translating basic science discoveries into new therapeutics for patients suffering from difficult to treat neuropsychiatric and neurodegenerative conditions.
Bauman, Melissa D, Carlson, Erin L, Cintrón-Pérez, Coral J, Pieper, Andrew A, Schumann, Cynthia M, Shin, Min-Kyoo, Taylor, Sandra L, Vázquez-Rosa, Edwin, Williams, Noelle S   +8 more
core   +2 more sources

Enhanced Epithelial Cell Uptake of Glycol Chitosan‐Coated PLGA Nanoparticles for Oral Drug Delivery

Advanced Therapeutics, EarlyView.
Here, glycol chitosan (GC)‐coated PLGA NPs are developed to enhance oral drug delivery by enabling dual‐pathway endocytosis via clathrin‐ and caveolae‐mediated mechanisms. Alginate layering coating on GC‐PLGA further improves oral insulin delivery, achieving sustained glucose reduction in diabetic mice.
Huiwen Pang, Wenxuan Yu, Youzhi Wu, Xuqiang Nie, Guojun Huang, Zhi Ping Xu, Chen Chen, Felicity Y. Han   +7 more
wiley   +1 more source

The primate connection [PDF]

Nature, 2010
Studies comparing HIV infection and its simian counterpart in different monkey species are filling gaps in knowledge, explains Bijal Trivedi.
openaire   +3 more sources

Primate modularity and evolution: first anatomical network analysis of primate head and neck musculoskeletal system [PDF]

, 2018
Network theory is increasingly being used to study morphological modularity and integration. Anatomical network analysis (AnNA) is a framework for quantitatively characterizing the topological organization of anatomical structures and providing an ...
A Goswami, A Porto, A Porto, AM Burrows, B Esteve-Altava, B Esteve-Altava, B Esteve-Altava, B Esteve-Altava, B Hallgrímsson, B Hallgrímsson, B Hallgrímsson, BM Waller, C Rolian, CF Ross, D Rasskin-Gutman, DE Lieberman, E Bullmore, G Marroig, G Marroig, GB Müller, GP Wagner, GP Wagner, J Ahn, KL Lewton, KL Schmidt, L Scheider, L Scheider, LA Parr, LR Monteiro, M Bastir, ML Moss, ML Zelditch, NM Young, NM Young, P Mitteroecker, R Cornette, R Diogo, R Diogo, R Laffont, RR Ackermann, RR Ackermann, SE Santana, SE Santana, SR Jackson, T Saucède, WR Atchley, X Li   +46 more
core   +2 more sources

Emerging Therapeutic Strategies for Hearing Loss

Advanced Therapeutics, EarlyView.
Challenges still exist in treating hearing loss in cases of severe damage to hair cells or spiral ganglion neurons. Here, a schematic diagram of cochlear sensory hair cells and auditory nerves is presented. It is found that in normal Corti organs, hair cells have upright stereocilia at the top and auditory neurons at the base. Ototoxic drugs, noise, or
Shanying Han, Tian Shen, Weiwei He, Hao Wei, Xiaolong Zhao, Wen Yang, Chuan Bu, Xinghua Tang, Yu Zhao, Jiangang Fan   +9 more
wiley   +1 more source

AAVR Expression is Essential for AAV Vector Transduction in Sensory Hair Cells

Advanced Science, EarlyView.
Decreased sensitivity to AAV vector transduction in the outer hair cells (OHCs) of adult mice is primarily attributed to reduction of AAVR (Kiaa0319l; Au040320). Knockout of AAVR reduces AAV vector transduction efficiency in both inner hair cells (IHCs) and OHCs in neonatal mice.
Fan Wu, Guisheng Chen, Rui Hu, Peiwen Liu, Jintao Lou, Wenji Zhao, Zuhong He, Suhua Sha, Yiqing Zheng   +8 more
wiley   +1 more source

Evolution and Mirror Neurons. An Introduction to the Nature of Self-Consciousness [PDF]

, 2005
Self-consciousness is a product of evolution. Few people today disagree with the evolutionary history of humans. But the nature of self-consciousness is still to be explained, and the story of evolution has rarely been used as a framework for studies on ...
Menant, Christophe
core  

The Morphological, Behavioral, and Transcriptomic Life Cycle of Anthrobots

Advanced Science, EarlyView.
DNA is thought to determine shape, behavior, and lifespan, with developmental plasticity reserved for stem cells, embryos, and species like amphibia. How much morphogenetic plasticity do adult somatic human cells exhibit? Anthrobots are a self‐organizing, motile synthetic living construct made of genetically normal human epithelial cells.
Gizem Gumuskaya, Nikolai Davey, Pranjal Srivastava, Andrew Bender, Léo Pio‐Lopez, Douglas Hazel, Michael Levin   +6 more
wiley   +1 more source

Electrical Stimulation Therapy – Dedicated to the Perfect Plastic Repair

Advanced Science, EarlyView.
This review discusses various types of electrical stimulation sources and materials, delving into the roles and mechanisms of electrical stimulation therapy in plastic surgery for tissue repair. This work broadens the clinical perspective of electrical stimulation, covering diverse repair needs from bone to soft tissues, and provides insights into ...
Kexin Deng, Ruizeng Luo, Ying Chen, Xiaoqiang Liu, Yuanyin Xi, Muhammad Usman, Xupin Jiang, Zhou Li, Jiaping Zhang   +8 more
wiley   +1 more source