Results 11 to 20 of about 675,523 (296)

In-depth analysis of T cell immunity and antibody responses in heterologous prime-boost-boost vaccine regimens against SARS-CoV-2 and Omicron variant [PDF]

Frontiers in Immunology, 2022
With the emergence of novel Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) Variants of Concern (VOCs), vaccination studies that elucidate the efficiency and effectiveness of a vaccination campaign are critical to assess the durability and ...
Natalie Heinen, Corinna Sophie Marheinecke, Clara Bessen, Arturo Blazquez-Navarro, Arturo Blazquez-Navarro, Toralf Roch, Toralf Roch, Ulrik Stervbo, Moritz Anft, Carlos Plaza-Sirvent, Sandra Busse, Mara Klöhn, Jil Schrader, Elena Vidal Blanco, Doris Urlaub, Carsten Watzl, Markus Hoffmann, Stefan Pöhlmann, Matthias Tenbusch, Eike Steinmann, Daniel Todt, Daniel Todt, Carsten Hagenbeck, Gert Zimmer, Gert Zimmer, Wolfgang Ekkehard Schmidt, Daniel Robert Quast, Nina Babel, Nina Babel, Ingo Schmitz, Stephanie Pfänder   +30 more
doaj   +3 more sources

Immunogenicity and reactogenicity after heterologous prime-boost vaccination with CoronaVac and ChAdox1 nCov-19 (AZD1222) vaccines

Human Vaccines & Immunotherapeutics, 2022
Mass vaccination with a safe and effective vaccine may be the best way to control the COVID-19 pandemic. Heterologous prime-boost vaccination with the CoronaVac and AZD1222 vaccines may increase the immunogenicity elicited by either vaccine alone.
Guy Cohen, Pawornrath Jungsomsri, Jirath Sangwongwanich, Kriangkrai Tawinprai, Taweegrit Siripongboonsitti, Thachanun Porntharukchareon, Kasiruck Wittayasak, Nawarat Thonwirak, Kamonwan Soonklang, Gaidganok Sornsamdang, Chirayu Auewarakul, Nithi Mahanonda   +11 more
doaj   +2 more sources

Heterologous prime-boost regimens using rAd35 and rMVA vectors elicit stronger cellular immune responses to HIV proteins than homologous regimens. [PDF]

PLoS ONE, 2012
We characterized prime-boost vaccine regimens using heterologous and homologous vector and gene inserts. Heterologous regimens offer a promising approach that focuses the cell-mediated immune response on the insert and away from vector-dominated ...
Silvia Ratto-Kim, Jeffrey R Currier, Josephine H Cox, Jean-Louis Excler, Anais Valencia-Micolta, Doris Thelian, Vicky Lo, Eddy Sayeed, Victoria R Polonis, Patricia L Earl, Bernard Moss, Merlin L Robb, Nelson L Michael, Jerome H Kim, Mary A Marovich   +14 more
doaj   +2 more sources

Prime-Boost Strategies in DNA Vaccines

, 2006
Induction of HIV-specific T-cell responses by vaccines may facilitate efficient control of HIV replication. Plasmid DNA vaccines and recombinant fowlpox virus (rFPV) vaccines are promising HIV-1 vaccine candidates, although delivering either vaccine alone may be insufficient to induce sufficient T-cell responses.
Dale, C Jane, Thomson, Scott, De Rose, Robert, Medveczky, C, Pamungkas, Joko, Boyle, David B, Ramshaw, Ian, Kent, Stephen J, Ranasinghe, Charani   +8 more
openaire   +5 more sources

Serum cytokine profiles associated with specific adjuvants used in a DNA prime-protein boost vaccination strategy. [PDF]

PLoS ONE, 2013
In recent years, heterologous prime-boost vaccines have been demonstrated to be an effective strategy for generating protective immunity, consisting of both humoral and cell-mediated immune responses against a variety of pathogens including HIV-1 ...
Rachel Buglione-Corbett, Kimberly Pouliot, Robyn Marty-Roix, Kim West, Shixia Wang, Egil Lien, Shan Lu   +6 more
doaj   +2 more sources

Immunogenicity of Low-Dose Prime-Boost Vaccination of mRNA Vaccine CV07050101 in Non-Human Primates

Viruses, 2021
Many different vaccine candidates against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent of COVID-19, are currently approved and under development. Vaccine platforms vary from mRNA vaccines to viral-vectored vaccines,
Neeltje van Doremalen, Robert J. Fischer, Jonathan E. Schulz, Myndi G. Holbrook, Brian J. Smith, Jamie Lovaglio, Benjamin Petsch, Vincent J. Munster   +7 more
doaj   +2 more sources

Optimisation of prime-boost immunization in mice using novel protein-based and recombinant vaccinia (Tiantan)-based HBV vaccine.

PLoS ONE, 2012
BackgroundA therapeutic vaccine for chronic hepatitis B virus (HBV) infection that enhances virus-specific cellular immune responses is urgently needed.
Hong Chen, Xia Chuai, Yao Deng, Bo Wen, Wen Wang, Shaoqing Xiong, Li Ruan, Wenjie Tan   +7 more
doaj   +2 more sources

Heterologous prime-boost: an important candidate immunization strategy against Tembusu virus

Virology Journal, 2020
Background Tembusu virus (TMUV), a newly emerging pathogenic flavivirus, spreads rapidly between ducks, causing massive economic losses in the Chinese duck industry. Vaccination is the most effective method to prevent TMUV.
Yuting Pan, Renyong Jia, Juping Li, Mingshu Wang, Shun Chen, Mafeng Liu, Dekang Zhu, Xinxin Zhao, Ying Wu, Qiao Yang, Zhongqiong Yin, Bo Jing, Juan Huang, Shaqiu Zhang, Lin Zhang, Yunya Liu, Yanlin Yu, Bin Tian, Leichang Pan, Mujeeb Ur Rehman, Anchun Cheng   +20 more
doaj   +1 more source

Intranasal plus subcutaneous prime vaccination with a dual antigen COVID-19 vaccine elicits T-cell and antibody responses in mice

Scientific Reports, 2021
We have developed a COVID-19 vaccine, hAd5 S-Fusion + N-ETSD, that expresses SARS-CoV-2 spike (S) and nucleocapsid (N) proteins with modifications to increase immune responses delivered using a human adenovirus serotype 5 (hAd5) platform.
Adrian Rice, Mohit Verma, Annie Shin, Lise Zakin, Peter Sieling, Shiho Tanaka, Joseph Balint, Kyle Dinkins, Helty Adisetiyo, Brett Morimoto, Wendy Higashide, C. Anders Olson, Shivani Mody, Patricia Spilman, Elizabeth Gabitzsch, Jeffrey T. Safrit, Shahrooz Rabizadeh, Kayvan Niazi, Patrick Soon-Shiong   +18 more
doaj   +1 more source

Mix-and-Match COVID-19 Vaccinations (Heterologous Boost): A Review

Infectious Disease Reports, 2022
Various safe and effective COVID-19 vaccines utilizing different platforms (mRNA, adenovirus vector, inactivated virus-based) are available against SARS-CoV-2 infection.
Ishan Garg, Abu Baker Sheikh, Suman Pal, Rahul Shekhar   +3 more
doaj   +1 more source