Results 41 to 50 of about 675,523 (296)

Prime-boost vectored malaria vaccines: Progress and prospects [PDF]

Human Vaccines, 2010
The difficulty of inducing protective immunity through antibodies against sporozoites led to efforts to assess vectored vaccines as a means of inducing protective T-cell immunity against the malaria liver-stage parasite. Although DNA vectored vaccines used alone were poorly immunogenic and not protective, high levels of parasite clearance in the liver ...
Hill AV, Reyes Sandoval A, O'Hara G, Ewer K, Lawrie A, Goodman A, NICOSIA, Alfredo, Folgori A, Colloca S, Cortese R, Gilbert SC, Draper SJ   +11 more
openaire   +5 more sources

Antibody effector analysis of prime versus prime-boost immunizations with a recombinant measles-vectored chikungunya virus vaccine

JCI Insight, 2021
Chikungunya is a mosquito-borne disease that causes periodic but explosive epidemics of acute disease throughout the tropical world. Vaccine development against chikungunya virus (CHIKV) has been hampered by an inability to conduct efficacy trials due to
Roland Tschismarov, Raphaël M. Zellweger, Min Jie Koh, Yan Shan Leong, Jenny G. Low, Eng Eong Ooi, Christian W. Mandl, Katrin Ramsauer, Ruklanthi de Alwis   +8 more
doaj   +1 more source

Oncolytic Rhabdovirus Vaccine Boosts Chimeric Anti-DEC205 Priming for Effective Cancer Immunotherapy

Molecular Therapy: Oncolytics, 2020
Prime-boost vaccination employing heterologous viral vectors encoding an antigen is an effective strategy to maximize the antigen-specific immune response. Replication-deficient adenovirus serotype 5 (Ad5) is currently being evaluated clinically in North
Fanny Tzelepis, Harsimrat Kaur Birdi, Anna Jirovec, Silvia Boscardin, Christiano Tanese de Souza, Mohsen Hooshyar, Andrew Chen, Keara Sutherland, Robin J. Parks, Joel Werier, Jean-Simon Diallo   +10 more
doaj   +1 more source

Combined prime-boost vaccination against tick-borne encephalitis (TBE) using a recombinant vaccinia virus and a bacterial plasmid both expressing TBE virus non-structural NS1 protein

BMC Microbiology, 2005
Background Heterologous prime-boost immunization protocols using different gene expression systems have proven to be successful tools in protecting against various diseases in experimental animal models.
Zakharova LG, Khoretonenko MV, Timofeev AV, Aleshin SE, Pashvykina GV, Stephenson JR, Shneider AM, Altstein AD   +7 more
doaj   +1 more source

Boosting BCG with recombinant modified vaccinia ankara expressing antigen 85A: Different boosting intervals and implications for efficacy trials [PDF]

, 2007
Objectives. To investigate the safety and immunogenicity of boosting BCG with modified vaccinia Ankara expressing antigen 85A (MVA85A), shortly after BCG vaccination, and to compare this first with the immunogenicity of BCG vaccination alone and second
Whelan, KT, Pathan, Ansar A, Poulton Ian, Nicola C Alder, Sander Clare R., Whelan, Kathryn T, Kathryn T Whelan, Fletcher, Helen A, Natalie E R Beveridge, Hill, AVS, Alder, NC, Fletcher, HA, Pathan Ansar A., Hill, Adrian VS, Sander, CR, Hill Adrian V. S., McShane Helen, Beveridge Natalie E. R., Pathan, AA, Beveridge, NER, Alder, Nicola C, Clare R Sander, Helen McShane, Ansar A Pathan, Ian Poulton, Poulton, Ian, Alder Nicola C., Whelan Kathryn T., Poulton, I, Sander, Clare R, Adrian V S Hill, Helen A Fletcher, Fletcher Helen A., McShane, H, Beveridge, Natalie ER, McShane, Helen   +35 more
core   +1 more source

Prime-Boost Immunization Strategies against Chikungunya Virus [PDF]

Journal of Virology, 2014
ABSTRACTChikungunya virus (CHIKV) is a reemerging mosquito-borne alphavirus that causes debilitating arthralgia in humans. Here we describe the development and testing of novel DNA replicon and protein CHIKV vaccine candidates and evaluate their abilities to induce antigen-specific immune responses against CHIKV.
Hallengard, D., Lum, F.-M., Kummerer, B. M., Lulla, A., Lulla, V., Garcia-Arriaza, J., Fazakerley, J. K., Roques, P., Le Grand, R., Merits, A., Ng, L. F. P., Esteban, M., Liljestrom, P.   +12 more
openaire   +2 more sources

DNA and Prime-Boost Immunizations.

, 2016
DNA and Prime-Boost Immunizations.
Weitao Huang (2158750), Hamada F. Rady (2158756), Judd E. Shellito (382009), Alistair J. Ramsay (789752), Guixiang Dai (2158753)   +4 more
core   +1 more source

Modeling the effect of boost timing in murine irradiated sporozoite prime-boost vaccines. [PDF]

, 2018
Vaccination with radiation-attenuated sporozoites has been shown to induce CD8+ T cell-mediated protection against pre-erythrocytic stages of malaria.
Cristina Fernandez-Arias, Min Zhang, Miguel A Herrero, Clemente F Arias, Francisco J Acosta, Clemente F. Arias, Miguel A. Herrero, Francisco J. Acosta, Moriya Tsuji   +8 more
core   +1 more source

Prime-Boost Vaccine Regimen for SjTPI and SjC23 Schistosome Vaccines, Increases Efficacy in Water Buffalo in a Field Trial in China

Frontiers in Immunology, 2019
Schistosomiasis remains a serious zoonotic disease in China and the Philippines. Water buffalo and cattle account for the majority of transmission. Vaccination of water buffalo is considered a key strategy to reduce disease prevalence.
Akram A. Da'Dara, Changlin Li, Xinling Yu, Mao Zheng, Jie Zhou, Lisa M. Shollenberger, Yue-sheng Li, Yue-sheng Li, Donald A. Harn   +8 more
doaj   +1 more source

mRNA prime-boost vaccination promotes clonal continuity in germinal center reactions and broadens SARS-CoV-2 variant coverage. [PDF]

Mol Ther
mRNA- and adenovirus-based (rAd) SARS-CoV-2 vaccines have been widely used in various homologous and heterologous prime-boost combinations. It remains unknown, however, which vaccination regimens effectively promote B cell clonal continuity (i.e., the ...
Ciancaglini M, Fixemer J, Seven C, Dimitrova M, Finozzi D, Weklak D, Kastner AL, Jönsson F, Wagner I, Vincenti I, Peters A, Newby ML, Crispin M, Merkler D, Kreppel F, Pinschewer DD.   +15 more
europepmc   +2 more sources