Results 61 to 70 of about 675,523 (296)
Summary of solicited local reactogenicity after prime and boost vaccination.
, 2019 Summary of solicited local reactogenicity after prime and boost vaccination.
Brenda Larkin (736365) +16 more
core +1 more source
Superior neutralizing antibody response and protection in mice vaccinated with heterologous DNA prime and virus like particle boost against HPAI H5N1 virus. [PDF]
PLoS ONE, 2011 BACKGROUND: Although DNA plasmid and virus-like particle (VLP) vaccines have been individually tested against highly pathogenic avian influenza (HPAI) H5N1 viruses, the combination of both vaccines into a heterologous prime-boost strategy against HPAI ...
Heng Ding +6 more
doaj +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Heterologous prime-boost immunization co-targeting dual antigens inhibit tumor growth and relapse
OncoImmunology, 2020 Therapeutic cancer vaccines aim to induce an effective immune response against cancer, and the effectiveness of these vaccines is influenced by the choice of immunogen, vaccine type, and immunization strategy.
Qianqian Guo +14 more
doaj +1 more source
rCSP/Ad35CS Heterologous Prime-Boost Regimens.
, 2014 C57BL/6 mice were immunized with rCSP formulated in GLA-SE or Ad35CS according to the regimens shown.rCSP/Ad35CS Heterologous Prime-Boost Regimens.
Hongfan Jin (632861) +19 more
core +1 more source
The effect of survey method on survey participation: analysis of data from the Health Survey for England 2006 and the Boost Survey for London. [PDF]
, 2010 BACKGROUND: There is a need for local level health data for local government and health bodies, for health surveillance and planning and monitoring of policies and interventions.
Tipping Sarah +17 more
core +2 more sources
Molecular Oncology, EarlyView.Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis +20 more
wiley +1 more source
HIV-1 Env DNA vaccine plus protein boost delivered by EP expands B- and T-cell responses and neutralizing phenotype in vivo. [PDF]
PLoS ONE, 2013 An effective HIV vaccine will most likely require the induction of strong T-cell responses, broadly neutralizing antibodies (bNAbs), and the elicitation of antibody-dependent cellular cytotoxicity (ADCC).
Kar Muthumani +13 more
doaj +1 more source
Molecular Oncology, EarlyView.Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi +2 more
wiley +1 more source
Инфекция и иммунитет, 2019 Avian influenza A (H1N1) in humans is characterized by severe clinical manifestation and high mortality. The main drawback of current human H5N1 vaccines is related to low immunogenicity.
I. Losev +3 more
doaj +1 more source