Results 51 to 60 of about 675,523 (296)

DNA priming for seasonal influenza vaccine: a phase 1b double-blind randomized clinical trial.

PLoS ONE, 2015
BackgroundThe efficacy of current influenza vaccines is limited in vulnerable populations. DNA vaccines can be produced rapidly, and may offer a potential strategy to improve vaccine immunogenicity, indicated by studies with H5 influenza DNA vaccine ...
Julie E Ledgerwood, Abbie R Bellamy, Robert Belshe, David I Bernstein, Srilatha Edupuganti, Shital M Patel, Phyllis Renehan, Thad Zajdowicz, Richard Schwartz, Richard Koup, Robert T Bailer, Galina V Yamshchikov, Mary E Enama, Uzma Sarwar, Brenda Larkin, Barney S Graham, VRC 701 study team   +16 more
doaj   +1 more source

Heterologous prime-boost H1N1 vaccination exacerbates disease following challenge with a mismatched H1N2 influenza virus in the swine model

Frontiers in Immunology, 2023
Influenza A viruses (IAVs) pose a significant threat to both human and animal health. Developing IAV vaccine strategies able to elicit broad heterologous protection against antigenically diverse IAV strains is pivotal in effectively controlling the ...
Vasilis C. Pliasas, Vasilis C. Pliasas, Peter J. Neasham, Peter J. Neasham, Maria C. Naskou, Rachel Neto, Philip G. Strate, J. Fletcher North, J. Fletcher North, Stephen Pedroza, Strickland D. Chastain, Ian Padykula, Ian Padykula, S. Mark Tompkins, S. Mark Tompkins, Constantinos S. Kyriakis, Constantinos S. Kyriakis, Constantinos S. Kyriakis   +17 more
doaj   +1 more source

Routes and doses for S4ΔaroD prime-boost vaccination groups.

, 2018
Routes and doses for S4ΔaroD prime-boost vaccination groups.
Katherine J. O’Malley (486282), Douglas S. Reed (344434), Jennifer L. Bowling (5879540), Kelly S. Cole (43113), Barbara J. Mann (270746), Elizabeth Stinson (5879543), Eileen M. Barry (298531), Prachi Namjoshi (5879546), Karsten R. O. Hazlett (212973)   +8 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Exploring heterologous prime-boost vaccination approaches to enhance influenza control in pigs

Veterinary Research, 2020
Influenza A viruses evolve rapidly to escape host immunity. In swine, this viral evolution has resulted in the emergence of multiple H1 and H3 influenza A virus (IAV) lineages in the United States (US) pig populations.
Chong Li, Marie R. Culhane, Maxim Cheeran, Lucina Galina Pantoja, Micah L. Jansen, Deborah Amodie, Martha A. Mellencamp, Montserrat Torremorell   +7 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

NK cell immune responses differ after prime and boost vaccination

, 2019
International audienceA better understanding of innate responses induced by vaccination is critical for designing optimal vaccines. Here, we studied the diversity and dynamics of the NK cell compartment after prime-boost immunization with the modified ...
Tchitchek, Nicolas, Martinon, Frédéric, Le Grand, Roger, Huot, Nicolas, Palgen, Jean‐louis, Dereuddre‐bosquet, Nathalie, Müller-Trutwin, Michaela, Levy, Yves, Lefebvre, Cécile, Beignon, Anne-Sophie, Rosenbaum, Pierre, Elhmouzi-Younes, Jamila, Cosma, Antonio, Hocini, Hakim   +13 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Trial 1 HAdV-vapA prime/Boost regime VapA total IgG ELISA response.

, 2016
Mean and SD VapA total IgG antibody levels at a 1:100 dilution of mouse sera pooled in the HAdV-vapA prime/boost vaccine regime per group over the duration of trial 1.
Mary D. Barton (843818), Thiru Vanniasinkam (798343), Carla Giles (2577964), Olasumbo Ndi (2577967)   +3 more
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source