Results 71 to 80 of about 675,523 (296)

Maximum local reactogenicity, prime vs boost, by treatment group.

, 2018
Bar graphs show the percentage of participants in each treatment group reporting the specified maximum severity during the reactogenicity period. Left panels (Prime) indicate the maximum severity over all 3 priming injections.
Magdalena E. Sobieszczyk (332353), M. Juliana McElrath (140060), Mary A. Allen (5774435), Shuying S. Li (262892), Gregory J. Wilson (2539195), David K. Clarke (5774447), Hong Van N. Tieu (5774438), Michael A. Egan (781415), Marnie L. Elizaga (102244), Ayuko Ota-Setlik (5774450), Theresa E. Latham (5774444), Ian Frank (10438), John H. Eldridge (781416), Nidhi K. Kochar (5774432), Brittany Sanchez (5774441), Christine Mhorag Hay (5774453), Drew Hannaman (221435), Kristen W. Cohen (106407), Rong Xu (296325)   +18 more
core   +1 more source

Heterologous prime-boost and intranasal inoculation with v-NY-S enhances production of SARS-CoV-2 spike-specific neutralizing antibodies.

, 2021
(A). Quantification of anti-spike antibody titers in primary (1°, transparent bars) and secondary (2°, filled bars) sera from mice by staining cell surface spike protein on insect cells using FACS, as shown by the mean fluorescence intensity (MFI).
Chun-Che Liao (7848628), Shiu-Lok Hu (156823), Yin-Shoiou Lin (11414237), Yu-Chiuan Wang (11414240), Wen-Ching Chen (1855111), Cheng-Pu Sun (3129720), Wen Chang (449265), Jia-Tsrong Jan (422327), Chi-Fei Kao (11414234), Hsiu-Hua Ma (11261964), Hui-Ying Ko (782055), Che Ma (1776586), Yu-Chi Chou (334781), Jian-Jong Liang (155301), Yu-Chan Chao (849471), Ying Lee (11414231), Sung-Chan Wei (849469), Rakesh Kulkarni (1464784), Yi-Ling Lin (63628)   +18 more
core   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Adenovirus-prime and baculovirus-boost heterologous immunization achieves sterile protection against malaria sporozoite challenge in a murine model [PDF]

, 2018
With the increasing prevalence of artemisinin-resistant malaria parasites, a highly efficacious and durable vaccine for malaria is urgently required.
Shahid M. Khan, Hill, A.V.S., Iyori, Mitsuhiro, Yusuf, Yenni, Yusuf, Y., Yoshii, Tatsuya, Salman, A.M., Yamamoto, Daisuke S, Mitsuhiro Iyori, Katarzyna A. Sala, Salman, Ahmed M, Ahmed M. Salman, Kunitaka Yoshida, Chris J. Janse, Tokoro, Masaharu, Tatsuya Yoshii, Iyori, M., Sumi Biswas, Yoshida, Shigeto, Janse, C.J., Blagborough, Andrew M, Biswas, S., Khan, Shahid M, Daisuke S. Yamamoto, Shigeto Yoshida, Andrew M. Blagborough, Blagborough, A.M., Sala, K.A., Hill, Adrian VS, Khan, S.M., Yoshii, T., Dulal, Pawan, Dulal, P., Masaharu Tokoro, Tokoro, M., Janse, Chris J, Yoshida, K., Yamamoto, D.S., Yoshida, Kunitaka, Biswas, Sumi, Sala, Katarzyna A, Yenni Yusuf, Pawan Dulal, Adrian V. S. Hill, Yoshida, S.   +44 more
core   +2 more sources

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

An evaluation of cytokine and cellular immune responses to heterologous prime-boost vaccination with influenza A/H7N7-A/H7N9 inactivated vaccine

Human Vaccines & Immunotherapeutics, 2020
The immunologic mechanisms underlying the improved serologic responses to heterologous prime-boost avian influenza vaccination are unclear. An exploratory analysis of the immune responses following 1 dose of influenza A/H7N9 inactivated vaccine in ...
Hana M El Sahly, George Makedonas, David Corry, Robert L Atmar, Abbie Bellamy, Kaitlyn Cross, Wendy A Keitel   +6 more
doaj   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

A Phase 1 randomized trial of homologous and heterologous filovirus vaccines with a late booster dose

npj Vaccines
Filoviruses, including Ebola, Marburg, Sudan, and Taï Forest viruses, are zoonotic pathogens that can cause severe viral hemorrhagic fever and death. Developing vaccines that provide durable, broad immunity against multiple filoviruses is a high global ...
Christina A. Rostad, Inci Yildirim, Carol Kao, Jumi Yi, Satoshi Kamidani, Etza Peters, Kathleen Stephens, Theda Gibson, Hui-Mien Hsiao, Karnail Singh, Paul Spearman, Courtney McCracken, Vivien Agbakoba, Kay M. Tomashek, Johannes B. Goll, Casey E. Gelber, Robert A. Johnson, Sujin Lee, Kristal Maner-Smith, Steven Bosinger, Eric A. Ortlund, Xuemin Chen, Larry J. Anderson, Jens Wrammert, Mehul Suthar, Nadine Rouphael, Evan J. Anderson   +26 more
doaj   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source