Results 41 to 50 of about 145,218 (264)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Prime editing – an update on the field [PDF]
Gene Therapy, 2021 Janine Scholefield, Patrick T. Harrison
openaire +2 more sources
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
On the Common Index Divisors of a Dihedral Field of Prime Degree
International Journal of Mathematics and Mathematical Sciences, 2007 A criterion for a prime to be a common index divisor of a dihedral field of prime degree is given. This criterion is used to determine the index of families of dihedral fields of degrees 5 and 7.
Blair K. Spearman +2 more
doaj +1 more source
Power Characteristics Analysis of a Novel Double-Stator Magnetic Geared Permanent Magnet Generator
Energies, 2017 This paper presents the design, fabrication and experimental power analysis of a novel double-stator magnetic geared permanent magnet (DSMGPM) machine which comprises of a double-stator permanent-magnet (PM) machine integrated a with triple rotor ...
Shehu Salihu Mustafa +3 more
doaj +1 more source
Floquet engineering of tilted and gapped Dirac bandstructure in 1T $$^\prime$$ ′ -MoS $$_2$$ 2
Scientific Reports, 2022 We have developed a rigorous theoretical formalism for Floquet engineering, investigating, and subsequently tailoring most crucial electronic properties of 1T $$^\prime$$ ′ -MoS $$_2$$ 2 by applying an external high-frequency dressing field within the ...
Andrii Iurov +6 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Minor Prime Factorization for n-D Polynomial Matrices over Arbitrary Coefficient Field
Complexity, 2018 In this paper, we investigate two classes of multivariate (n-D) polynomial matrices whose coefficient field is arbitrary and the greatest common divisor of maximal order minors satisfy certain condition.
Jinwang Liu, Dongmei Li, Licui Zheng
doaj +1 more source