Results 81 to 90 of about 729,819 (318)
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Disjunctive Ideals of Almost Distributive Lattices
Discussiones Mathematicae - General Algebra and Applications, 2022 The concept of disjunctive ideals is introduced in an Almost Distributive Lattice (ADL). It is proved that the set of all disjunctive ideals of an ADL forms a complete lattice.
Rafi N., Srujana M., Rao T. Srinivasa
doaj +1 more source
, 2006 A characterization of an $h$-hemiregular hemiring in terms of a fuzzy $h$-ideal is provided. Some properties of prime fuzzy $h$-ideals of $h$-hemiregular hemirings are investigated.
Aho +22 more
core +2 more sources
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Prime ideals of the Burnside ring of a saturated fusion system [PDF]
, 2022 Nicolas Lemoine
openalex +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Interplay between RNA‐protein interactions and RNA structures in gene regulation
FEBS Open Bio, EarlyView.Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko +2 more
wiley +1 more source
A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms
FEBS Open Bio, EarlyView.We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley +1 more source
Prime Structures in a Morita Context
, 2018 In this paper, we study on the primeness and semiprimeness of a Morita context related to the rings and modules. Necessary and sufficient conditions are investigated for an ideal of a Morita context to be a prime ideal and a semiprime ideal.
Calci, Mete Burak +3 more
core
Molecular determinants of signal transduction in tropomyosin receptor kinases
FEBS Open Bio, EarlyView.Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley +1 more source