Results 111 to 120 of about 315,776 (265)
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
$N$-recognizability of Groups $ Alt_p\times Alt_5$,\\ Where $p>1361$ Is a Prime Number
Известия Иркутского государственного университета: Серия "Математика"$N$-recognizability of Groups $ Alt_p\times Alt_5$, Where $p>1361$ Is a Prime Number} Given a finite group $L$, let $N(L)$ denote the set of its conjugacy class sizes.
I. B. Gorshkov, V. D. Shepelev
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
A Prime-Number/Uniform Angular Distribution Criterion for Blade Vibration Reduction
Engineering TransactionsCurrently, the vibration noise of casting cleaning equipment exceeds 95 dB, which not only shortens the equipment’s service life but also jeopardizes workers’ health.
Yong Li +5 more
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Empirically testing a relationship between cooperation and the prime numbers
Royal Society Open ScienceTheoretical models suggest a relationship between cooperation and the prime numbers. In environments where agents play multiple one-shot prisoner’s dilemma games per generation, cooperators evolve to fixation more frequently when cooperating on a ...
Tim Johnson
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Prime Numbers in Prime Numbers Up To 5 Digits
, 2019 This work brings prime numbers formed digits appearing in prime number. We have considered all the prime numbers from single digits to 5 digits. For higher digits refer to further works. This type of work is known in the literature but still is not aware of references in this direction. These shall be filled as long as we know them.
openaire +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source