Results 41 to 50 of about 145,068 (247)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Investigating Schema-Free Encoding of Categorical Data Using Prime Numbers in a Geospatial Context
ISPRS International Journal of Geo-Information, 2019 Prime numbers are routinely used in a variety of applications, e.g., cryptography and hashing. A prime number can only be divided by one and the number itself.
Martin Sudmanns
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
About finding of prime numbers that follow after given prime number without using computer
Дифференциальная геометрия многообразий фигур, 2020 It is shown how to define one or several prime numbers following after given prime number without using computer only by calculating several arithmetic progressions. Five examples of finding such prime numbers are given.
V.S. Malakhovsky
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
A Scale Invariant Distribution of the Prime Numbers
Computation, 2015 The irregular distribution of prime numbers amongst the integers has found multiple uses, from engineering applications of cryptography to quantum theory.
Wayne S. Kendal, Bent Jørgensen
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Some Observations on the Greatest Prime Factor of an Integer
Annales Mathematicae Silesianae, 2023 We examine the multiplicity of the greatest prime factor in k-full numbers and k-free numbers. We generalize a well-known result on greatest prime factors and obtain formulas related with the Riemann zeta function.
Jakimczuk Rafael
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FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source