Results 61 to 70 of about 145,068 (247)

Equations for a potential algebraic approach to the twin prime conjecture. Addendum to: "On the numbers that determine the distribution of twin primes" [PDF]

open access: yesSurveys in Mathematics and its Applications
This is an Addendum to: Article: On the numbers that determine the distribution of twin primes Author: Antonie Dinculescu Published in: Surveys in Mathematics and its Applications, 13 (2018), 171–181. Full text:
Antonie Dinculescu
doaj  

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

Pseudo-prime number simulation and its application for security purpose

open access: yesMATEC Web of Conferences, 2018
Many public cryptography schemes rely on the use of prime numbers like for encryption and decryption. A prime number is one number that is widely used and large and consists of hundreds of digits, so it takes time to test whether the numbers are prime or
Rahim Robbi   +10 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

open access: yesMolecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken   +7 more
wiley   +1 more source

The emergence of the Mersenne Star: a new geometry of prime numbers bridging physics and artificial general intelligence

open access: yesArab Journal of Basic and Applied Sciences
This paper introduces a new key geometric way to understand Mersenne prime numbers. It discovers a shape called the Mersenne Star, which appears naturally from a special sequence named the Quanta Prime Sequence (QPS).
Moustafa Ibrahim
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Eigenvalues of Sturm-Liouville operators and prime numbers

open access: yesElectronic Journal of Differential Equations, 2017
We show that there is no function $q(x)\in L_2(0,1)$ which is the potential of a Sturm-Liouville problem with Dirichlet boundary condition whose spectrum is a set depending nonlinearly on the set of prime numbers as suggested by Mingarelli [7].
Rauf Amirov, Ibrahim Adalar
doaj  

Una aproximación a la Conjetura de Goldbach

open access: yesEcomatemático, 2019
One of the mathematical problems that seems to be very true, but lacks a demonstration, is Goldbach's conjecture posed since 1742.The present article makes a critical analysis, where several proposals for its solution were compiled, with a ...
Ingrid Yurley Parada-Buitrago   +2 more
doaj   +1 more source

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