Results 101 to 110 of about 115,699 (314)

Germline variants in CDKN2A wild‐type melanoma prone families

Molecular Oncology, EarlyView.
Among melanoma‐prone families, wild‐type for CDKN2A and CDK4, some have pathogenic variants in genes not usually linked to melanoma. Furthermore, rare XP‐related variants and variants in MC1R are enriched in such families. Germline pathogenic variants in CDKN2A are well established as an underlying cause of familial malignant melanoma. While pathogenic
Gjertrud T. Iversen, Marie Loeng, Amalie Lund Holth, Per E. Lønning, Jürgen Geisler, Stian Knappskog   +5 more
wiley   +1 more source

On prime essential rings [PDF]

Bulletin of the Australian Mathematical Society, 1993
A ring A is prime essential if A is semiprime and every prime ideal of A has a nonzero intersection with each nonzero ideal of A. We prove that any radical (other than the Baer's lower radical) whose semisimple class contains all prime essential rings is not special. This yields non-speciality of certain known radicals and answers some open questions.
openaire   +2 more sources

Prime Ideals in Noetherian Rings [PDF]

arXiv, 2011
In this short note we study the links of certain prime ideals of a noetherian ring R. We first give the definition of a link krull symmetric noetherian ring R. We then prove theorem 9 that states that for any linked prime ideals P' and Q' of the polynomial ring R[X] where R is a link krull symmetric noetherian ring, if The prime ideal P' is extended ...
arxiv  

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Automorphism-Liftable Modules [PDF]

arXiv, 2019
In this paper, we describe all automorphism-liftable torsion modules over non-primitive hereditary Noetherian prime rings. We also study automorphism-liftable non-torsion modules over not necessarily commutative Dedekind prime ...
arxiv  

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

One sided generalized (σ,τ)-derivations on rings

Boletim da Sociedade Paranaense de Matemática, 2018
Let R be a prime ring with characteristic not 2 and σ,τ,λ,μ,α,β automorphisms of R. Let h be a nonzero left (resp. right)-generalized (σ,τ)-derivation of R and I,J nonzero ideals of R and a∈R.
Evrim Guven
doaj   +1 more source

Polynomial Rings Whose Primes are Stci [PDF]

arXiv, 2007
Let R be a commutative ring with1 and R[X] be the polynomial ring over R. We determine the underlying ring R over which the polynomial ring R[X] has the property that all its prime ideals are set theoretic complete intersections.
arxiv  

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

On z-Ideals and z ◦ -Ideals of Power Series Rings

Journal of Mathematical Extension, 2013
Let R be a commutative ring with identity and R[[x]] be the ring of formal power series with coefficients in R. In this article we consider sufficient conditions in order that P[[x]] is a minimal prime ideal of R[[x]] for every minimal prime ideal P ...
A. Rezaei Aliabad, R. Mohamadian
doaj