Results 81 to 90 of about 1,089,172 (249)
DNA ligase LigE increases bacterial transformation with damaged extracellular DNA
FEBS Letters, EarlyView.The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan +4 more
wiley +1 more source
Centralizing Automorphisms of Prime Rings [PDF]
Canadian Mathematical Bulletin, 1976 AbstractLet R be a prime ring and T be a nontrivial automorphism of R. If xxT—xTx is in the center of the ring for every x in R, then R is a commutative integral domain.
openaire +2 more sources
FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source
How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome
FEBS Letters, EarlyView.In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini +3 more
wiley +1 more source
Prime Lie Rings of Derivations of Commutative Rings II
, 2013 [[abstract]]Let R be a 2-torsionfree commutative ring, and D a Lie subring and an R-submodule of Der(R) such that R is D-prime.
Lee, Pjek-Hwee; Liu, Cheng-Kai
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
On z-Ideals and z ◦ -Ideals of Power Series Rings
Journal of Mathematical Extension, 2013 Let R be a commutative ring with identity and R[[x]] be the ring of formal power series with coefficients in R. In this article we consider sufficient conditions in order that P[[x]] is a minimal prime ideal of R[[x]] for every minimal prime ideal P ...
A. Rezaei Aliabad, R. Mohamadian
doaj
On the Structure of Semiderivations in Prime Rings [PDF]
Proceedings of the American Mathematical Society, 1990 Let R R be a prime ring. By a semiderivation associated with a function
openaire +2 more sources
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source