Results 121 to 130 of about 44,957 (356)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Integral group ring of the McLaughlin simple group
, 2007 We consider the Zassenhaus conjecture for the normalized unit group of the integral group ring of the McLaughlin sporadic group McL.
Bódi, Viktor +3 more
core
A Note on a Prime Ring with a Maximal Annihilator Right Ideal
, 1965 A ring R is called a prime ring [1] if and only if a·R·b = 0 implies that a = 0 or b = 0 for all a, b ϵ R. Hence if R is a prime ring and a is a non-zero element of R, a·R ≠ 0 and R·a ≠ 0.
Kwangil Koh
core +1 more source
On derivations in \sigma-prime rings
International Journal of Algebra, 2007 Summary: Let \((R,\sigma)\) be a 2-torsion free \(\sigma\)-prime ring with involution \(\sigma\) and \(d\) be a nonzero derivation of \(R\). In the present paper it is shown that if \(d\) is centralizing, then \(R\) is commutative. Furthermore, if \(d\) commutes with \(\sigma\) and \(0\neq I\) is a \(\sigma\)-ideal of \(R\) such that either \([d(x),d(y)
Oukhtite, L., Salhi, S.
openaire +2 more sources
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
On (σ, δ)(S, 1) rings and their extensions [PDF]
Mathematica Moravica, 2017 Let R be a ring, σ an endomorphism of R and δ a σ derivation of R. We recall that R is called an (S, 1)-ring if for a, b _ R, ab = 0 implies aRb = 0. We involve σ and δ to generalize this notion and say that R is a (σ, δ) - (S, 1) ring if for a, b _ R ...
Bhat Kumar Vijay
doaj
Approximaitly Semi-Prime Submodules and Some Related Concepts
Ibn Al-Haitham Journal for Pure and Applied Sciences, 2019 We introduce in this paper the concept of approximaitly semi-prime submodules of unitary left -module over a commutative ring with identity as a generalization of a prime submodules and semi-prime submodules, also generalization of quasi-prime ...
Ali Sh. Ajeel, Haibat K. Mohammad ali
doaj +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
The Conversion of 5,5′-Bi(1,2,3-dithiazolylidenes) into Isothiazolo[5,4-d]isothiazoles
Molecules, 2018 Thermolysis of 4,4′-dichloro-, 4,4′-diaryl-, and 4,4′-di(thien-2-yl)-5,5′-bi(1,2,3-dithiazol-ylidenes) affords the respective 3,6-dichloro-, 3,6-diaryl- and 3,6-di(thien-2-yl)isothiazolo[5,4-d]-isothiazoles in low to high yields ...
Lidia S. Konstantinova +7 more
doaj +1 more source
The Prime Radical in Alternative Rings [PDF]
Proceedings of the American Mathematical Society, 1976 The characterization by J. Levitzki of the prime radical of an associative ring R R as the set of strongly nilpotent ...
openaire +2 more sources