Results 81 to 90 of about 441,153 (259)
TRPM8 levels determine tumor vulnerability to channel agonists
Molecular Oncology, EarlyView.TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo +18 more
wiley +1 more source
FUZZY IDEALS OF NEAR-RINGS WITH INTERVAL VALUED MEMBERSHIP FUNCTIONS [PDF]
Journal of Sciences, Islamic Republic of Iran, 2001 In this paper, for a complete lattice L, we introduce interval-valued L-fuzzy ideal (prime ideal) of a near-ring which is an extended notion of fuzzy ideal (prime ideal) of a near-ring. Some characterization and properties are discussed.
doaj
$\mathscr{T}$-Commuting Generalized Derivations on Ideals and Semi-Prime Ideal
Boletim da Sociedade Paranaense de MatemáticaThis paper's primary goal is to look at a quotient ring $\mathscr{A}/\mathscr{T}$ structure, where $\mathscr{A}$ is an arbitrary ring and $\mathscr{T}$ is a semi-prime ideal of $\mathscr{A}$.
Nadeem ur Rehman, Hafedh M. Alnoghashi
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One sided generalized (σ,τ)-derivations on rings
Boletim da Sociedade Paranaense de Matemática, 2018 Let R be a prime ring with characteristic not 2 and σ,τ,λ,μ,α,β automorphisms of R. Let h be a nonzero left (resp. right)-generalized (σ,τ)-derivation of R and I,J nonzero ideals of R and a∈R.
Evrim Guven
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Prime ideal structure of rings of bounded continuous functions [PDF]
, 1968 Mark Mandelker
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Molecular Oncology, EarlyView.Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop +10 more
wiley +1 more source
About unital and non-unital duo rings [PDF]
Proceedings of the Estonian Academy of SciencesSeveral results about one-sided duo rings and duo rings are generalized from the case of unital rings to the case of arbitrary associative rings in this paper.
Mart Abel, Eva-Lotta Elmanovitš
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Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source