Results 81 to 90 of about 173,695 (219)

Principal Binets

open access: yesDiscrete & Computational Geometry
Abstract Conjugate parametrizations of surfaces were first discretized almost a century ago as quad meshes with planar faces. With the recent development of discrete differential geometry, two discretizations of principal curvature line parametrizations were discovered: circular nets and conical nets, both of which are special cases ...
Niklas C. Affolter, Jan Techter
openaire   +2 more sources

Informed principal with correlation [PDF]

open access: yesGames and Economic Behavior, 2008
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +6 more sources

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

open access: yesFEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara   +3 more
wiley   +1 more source

Supervisi Kepala Sekolah dalam Peningkatan Profesionalisme Guru di SMA Primaganda Jombang

open access: yesAl-Idaroh: Jurnal Studi Manajemen Pendidikan Islam, 2019
The quality of learning is strongly influenced by the professional quality of teacher performance, therefore efforts to improve the professional abilities of teachers in carrying out the learning and teaching process can be through supervision assistance.
Ali Mustofa, Maulana Adinata
doaj  

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

open access: yesFEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

What leadership behaviors were demonstrated by the principal in a high poverty, high achieving elementary school?

open access: yesCogent Education, 2016
Examined through the lens of leadership, were the behaviors of a principal as perceived by stakeholders. The following themes emerged: (1) Educating the Whole Child, with the subthemes: (a) providing basic needs; (b) academic interventions based on ...
E. Hayet J. Woods, Barbara N. Martin
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

open access: yesMolecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce   +11 more
wiley   +1 more source

Principal as Gatekeeper - A Discussion Paper on Educational Leadership

open access: yesCanadian Journal for New Scholars in Education, 2018
: The focal point of school leadership and administration has been largely on the singular person – the school principal. This discussion paper reconsiders and troubles the gatekeeping role of the school principal in the context of popular media ...
Astrid Helene Kendrick
doaj  

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