Results 151 to 160 of about 601,312 (265)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Controllable protein design via autoregressive direct coupling analysis conditioned on principal components. [PDF]

PLoS Comput Biol
Caredda F, Gennai L, De Los Rios P, Pagnani A.   +3 more
europepmc   +1 more source

Author Correction: mbDenoise: microbiome data denoising using zero-inflated probabilistic principal components analysis. [PDF]

Genome Biol, 2023
Zeng Y, Li J, Wei C, Zhao H, Wang T.
europepmc   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Assessment of cardiac allograft vasculopathy in heart transplant patients using multidimensional dynamic CTA and principal components analysis. [PDF]

BMC Med Imaging
Zhang X, Yang M, Huang T, Qin Q, Qian P, Luo Y, Wang J.   +6 more
europepmc   +1 more source

Multilevel hybrid principal components analysis for region-referenced functional electroencephalography data. [PDF]

Stat Med, 2022
Campos E, Wolfe Scheffler A, Telesca D, Sugar C, DiStefano C, Jeste S, Levin AR, Naples A, Webb SJ, Shic F, Dawson G, Faja S, McPartland JC, Şentürk D, Autism Biomarkers Consortium for Clinical Trials.   +14 more
europepmc   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Body composition-derived principal components partially explain sex and age effects on bone mineral density in type 2 diabetes mellitus. [PDF]

Front Endocrinol (Lausanne)
Cheng D, Chen Y, Cai Y, Wang J, Yang S, Mao J, Wang Y.   +6 more
europepmc   +1 more source

ERStruct: a fast Python package for inferring the number of top principal components from whole genome sequencing data. [PDF]

BMC Bioinformatics, 2023
Yang J, Xu Y, Yao M, Wang G, Liu Z.
europepmc   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source