Results 161 to 170 of about 601,312 (265)

Principal components from untargeted cerebrospinal fluid metabolomics associated with Alzheimer's disease biomarkers. [PDF]

Neurobiol Aging, 2022
Dong R, Denier-Fields DN, Lu Q, Suridjan I, Kollmorgen G, Wild N, Betthauser TJ, Carlsson CM, Asthana S, Johnson SC, Zetterberg H, Blennow K, Engelman CD.   +12 more
europepmc   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Association of Nontraditional Lipid Parameters With Long-Term Prognosis of Acute Ischemic Stroke: A Principal Components Analysis. [PDF]

J Am Heart Assoc
Lin H, Xie W, Huang S, Lou J, Zhang R, Yu B, Zhou G, Pan Y, Wu T, Huang X, Chen F, Zhang C, Zhu Y, Weng Y, Yang D, Chen G.   +15 more
europepmc   +1 more source

Bayesian multivariate sparse functional principal components analysis with application to longitudinal microbiome multiomics data. [PDF]

Ann Appl Stat, 2022
Jiang L, Elrod C, Kim JJ, Swafford AD, Knight R, Thompson WK.   +5 more
europepmc   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Matching heterogeneous cohorts by projected principal components reveals two novel Alzheimer's disease-associated genes in the Hispanic population. [PDF]

Alzheimers Dement
Willett JDS, Waqas M, Naumenko S, Mullin K, Hecker J, Bertram L, Lange C, Vlachos I, Hide W, Tanzi RE, Prokopenko D.   +10 more
europepmc   +1 more source

A practical introduction to EEG Time-Frequency Principal Components Analysis (TF-PCA). [PDF]

Dev Cogn Neurosci, 2022
Buzzell GA, Niu Y, Aviyente S, Bernat E.
europepmc   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Contrastive Functional Principal Components Analysis. [PDF]

Proc AAAI Conf Artif Intell
Zhang E, Li D.
europepmc   +1 more source

An Exploration of Pathologies of Multilevel Principal Components Analysis in Statistical Models of Shape. [PDF]

J Imaging, 2022
Farnell DJJ.
europepmc   +1 more source