Results 181 to 190 of about 601,312 (265)

An analysis of pacing profiles in sprint kayak racing using functional principal components and hidden Markov models. [PDF]

PLoS One
Estreich H, Bullock N, Osborne M, Santos-Fernandez E, Wu PP.   +4 more
europepmc   +1 more source

Stepwise Covariance-Free Common Principal Components (CF-CPC) With an Application to Neuroscience. [PDF]

Front Neurosci, 2021
Riaz U, Razzaq FA, Hu S, Valdés-Sosa PA.   +3 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Combined analysis of multiple linear regression and principal components for predicting performance indicators in broiler chickens under commercial conditions. [PDF]

Poult Sci
Freitas RC, Calderano AA, Oliveira CH, Neto MG, Genova JL.   +4 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Exploring body composition and physical condition profiles in relation to playing time in professional soccer: a principal components analysis and Gradient Boosting approach. [PDF]

Front Physiol
Ulloa-Díaz D, Fábrica-Barrios G, Jorquera-Aguilera C, Guede-Rojas F, Pérez-Contreras J, Lozano-Jarque D, Carvajal-Parodi C, Romero-Vera L.   +7 more
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Improving racial data equity among minority groups in South Carolina using COVID-19 as an example: application of principal components analysis. [PDF]

Popul Health Metr
Rubaiya F, O'Connor J, Kolev LN, Antill JM, Iiams M, Martin LA, Joseph CZ, Youngblood C, Almeda-Garrett J, Kelemen LE.   +9 more
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Principal components of type 2 diabetes risk: an exploratory factor analysis in an Iranian cohort. [PDF]

BMC Public Health
Geravandi S, Emamgholipour S, Pakdaman M, Sari AA, Esmaeili A.   +4 more
europepmc   +1 more source