Results 181 to 190 of about 689,927 (311)

Limitations of principal components in quantitative genetic association models for human studies. [PDF]

Elife, 2023
Yao Y, Ochoa A.
europepmc   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

The Relation between Predictability and Complexity: Domestic and Public Consumption in the Romanian Economy [PDF]

We continue with the problem of the relation between predictability and complexity in the Romanian economy, analyzing other two components of GDP: domestic consumption and public consumption.
Saman, Corina, Stanica, Cristian, Scutaru, Cornelia   +2 more
core  

Fast Bayesian Functional Principal Components Analysis. [PDF]

J Comput Graph Stat
Sartini J, Zhou X, Selvin E, Zeger S, Crainiceanu CM.   +4 more
europepmc   +1 more source

The metabolic spatial covariance pattern of definite idiopathic normal pressure hydrocephalus: an FDG PET study with principal components analysis. [PDF]

Alzheimers Res Ther, 2023
Rau A, Schröter N, Blazhenets G, Maurer C, Urbach H, Meyer PT, Frings L.   +6 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Modelling the Load Curve of Aggregate Electricity Consumption Using Principal Components [PDF]

Since oil is a non-renewable resource with a high environmental impact, and its most common use is to produce combustibles for electricity, reliable methods for modelling electricity consumption can contribute to a more rational employment of this ...
Matteo Manera, Angelo Marzullo
core  

Quantitative determination of trace principal components with high specific activity in menotropins. [PDF]

Front Bioeng Biotechnol
Sun Y, Li H, Hu X, Luo S, Zhang X, Wang L, Li Y, Lyu P, Li J.   +8 more
europepmc   +1 more source

The Application of Clustering on Principal Components for Nutritional Epidemiology: A Workflow to Derive Dietary Patterns. [PDF]

Nutrients, 2022
Maugeri A, Barchitta M, Favara G, La Mastra C, La Rosa MC, Magnano San Lio R, Agodi A.   +6 more
europepmc   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source