Results 171 to 180 of about 2,294,043 (337)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Time-Varying Functional Principal Components for Non-Stationary EpCO$$_2$$ in Freshwater Systems [PDF]

, 2022
Amira Elayouty, Marian Scott, Claire A. Miller   +2 more
openalex   +1 more source

Bayesian multivariate sparse functional principal components analysis with application to longitudinal microbiome multiomics data. [PDF]

Ann Appl Stat, 2022
Jiang L, Elrod C, Kim JJ, Swafford AD, Knight R, Thompson WK.   +5 more
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Principal components from untargeted cerebrospinal fluid metabolomics associated with Alzheimer's disease biomarkers. [PDF]

Neurobiol Aging, 2022
Dong R, Denier-Fields DN, Lu Q, Suridjan I, Kollmorgen G, Wild N, Betthauser TJ, Carlsson CM, Asthana S, Johnson SC, Zetterberg H, Blennow K, Engelman CD.   +12 more
europepmc   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

PEMBUATAN PERANGKAT LUNAK PENGENALAN WAJAH MENGGUNAKAN PRINCIPAL COMPONENTS ANALYSIS

Jurnal Informatika, 2001
Face recognition is one of many important researches, and today, many applications have implemented it. Through development of techniques like Principal Components Analysis (PCA), computers can now outperform human in many face recognition tasks ...
Kartika Gunadi, Sonny Reinard Pongsitanan   +1 more
doaj  

Application of principal component analysis in phase-shifting photoelasticity

, 2016
Juan Antonio Quiroga, José A. Gómez‐Pedrero   +1 more
openalex   +1 more source

Pengenalan Wajah Menggunakan Metode Principal Component Analysis (PCA) dan Canberra Distance [PDF]

, 2017
Perani Rosyani
openalex   +1 more source

Neural Network Characterization and Entropy Regulated Data Balancing Through Principal Component Analysis

, 2023
David Yevick, Karolina Hutchison
openalex   +1 more source