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Introduction to Statistical Methods to Analyze Large Data Sets: Principal Components Analysis
Science Signaling, 2011 Lecture notes, slides, and problem sets introduce the mathematical concepts behind principal components analysis. This Teaching Resource provides lecture notes, slides, and a problem set for a series of lectures from a course entitled “Systems Biology ...
N. R. Clark, Avi Ma’ayan
semanticscholar +1 more source
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
Multivariate statistical analysis of parameters of surface water quality in Vojvodina
Zaštita Materijala, 2014 Monitoring of chemical and physical-chemical parameters of surface water is a very important factor in the quality control and management. Surface water quality is largely determined by atmospherics (natural process) and the discharge of industrial and ...
Borko Matijević +4 more
doaj +1 more source
pcaExplorer: an R/Bioconductor package for interacting with RNA-seq principal components
BMC Bioinformatics, 2018 Principal component analysis (PCA) is frequently used in genomics applications for quality assessment and exploratory analysis in high-dimensional data, such as RNA sequencing (RNA-seq) gene expression assays.
F. Marini, H. Binder
semanticscholar +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
المجلة الدولية للأداء الاقتصادي, 2018 This work aims to apply principal components analysis and cluster analysis to determine the Agricultural capacities of Algeria. We find four agricultural areas. These areas characterized by the production of citrus fruits, potatoes and potatoes, cereals
Houssame Eddine BALOULI, Lazhar CHINE
doaj
Automated Detection of Myocardial Infarction Using a Gramian Angular Field and Principal Component Analysis Network [PDF]
, 2019 Gong Zhang +4 more
openalex +1 more source
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source