Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
A least squares approach to Principal Component Analysis for interval valued data [PDF]
Principal Component Analysis (PCA) is a well known technique the aim of which is to synthesize huge amounts of numerical data by means of a low number of unobserved variables, called components.
D'Urso, Pierpaolo, Giordani, Paolo
core
On the Construct Validity of the Reading Section of the University of Tehran English Proficiency Test [PDF]
Journal of English Language Teaching and Learning, 2011 University of Tehran administers a test known as The University of Tehran English Proficiency Test (the UTEPT) to PhD candidates on a yearly basis. By definition, the test can be considered a high-stakes one. The validity of high stakes tests needs to be
Mohammad Salehi
doaj
Punching a Ticket to Cooperstown
Journal of Statistics Education, 2019 When exposed to principal components analysis for the first time, students can sometimes miss the primary purpose of the analysis. Often the focus is solely on data reduction and what to do after the dimensions of the data have been reduced is ignored ...
Philip A. Yates
doaj +1 more source
The metabolic spatial covariance pattern of definite idiopathic normal pressure hydrocephalus: an FDG PET study with principal components analysis. [PDF]
Alzheimers Res Ther, 2023 Rau A +6 more
europepmc +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Generalized power method for sparse principal component analysis [PDF]
In this paper we develop a new approach to sparse principal component analysis (sparse PCA). We propose two single-unit and two block optimization formulations of the sparse PCA problem, aimed at extracting a single sparse dominant principal component of
Journée, Michel +3 more
core
Initial Steps towards a Multilevel Functional Principal Components Analysis Model of Dynamical Shape Changes. [PDF]
J Imaging, 2023 Farnell DJJ, Claes P.
europepmc +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Multilevel hybrid principal components analysis for region-referenced functional electroencephalography data. [PDF]
Stat Med, 2022 Campos E +14 more
europepmc +1 more source