Results 91 to 100 of about 26,129,289 (257)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Smoothing dynamic positron emission tomography time courses using functional principal components [PDF]
, 2009 A functional smoothing approach to the analysis of PET time course data is presented. By borrowing information across space and accounting for this pooling through the use of a nonparametric covariate adjustment, it is possible to smooth the PET time ...
Aston, John A. D. +2 more
core
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Principal component analysis of functional principal components.
, 2018 Principal component analysis of functional principal components.
Seungmi Yang (611033) +6 more
core +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
The Measurement of the Energy Intensity of Manufacturing Industries: A Principal Components Analysis [PDF]
Energy intensity is the ratio of energy use to output. Most industries deal with several energy sources and outputs. This leads to the usual difficulties of aggregating heterogeneous inputs and outputs.
Cote, Bruno, Bernard, Jean-Thomas
core
Components Generated by the Principal Components Analysis.
, 2016 Components Generated by the Principal Components Analysis.
Elizabeth DiNenno (775799) +14 more
core +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
PEMBUATAN PERANGKAT LUNAK PENGENALAN WAJAH MENGGUNAKAN PRINCIPAL COMPONENTS ANALYSIS
Jurnal Informatika, 2001 Face recognition is one of many important researches, and today, many applications have implemented it. Through development of techniques like Principal Components Analysis (PCA), computers can now outperform human in many face recognition tasks ...
Kartika Gunadi +1 more
doaj