Results 71 to 80 of about 95,004 (254)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

N′-(5-Chloro-2-hydroxybenzylidene)-4-methoxybenzohydrazide

Acta Crystallographica Section E, 2012
The asymmetric unit of the title compound, C15H13ClN2O3, contains two independent hydrazone molecules. Each molecule adopts an E configuration with respect to the methylidene unit and forms an intramolecular O—H...N hydrogen bond. The principal
Yao Tan
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

JustSTART: How to Find an RSA Authentication Bypass on Xilinx UltraScale(+) with Fuzzing

Transactions on Cryptographic Hardware and Embedded Systems
Fuzzing is a well-established technique in the software domain to uncover bugs and vulnerabilities. Yet, applications of fuzzing for security vulnerabilities in hardware systems are scarce, as principal reasons are requirements for design information ...
Maik Ender, Felix Hahn, Marc Fyrbiak, Amir Moradi, Christof Paar   +4 more
doaj   +1 more source

Utility Of Stress-Texture Characteristics Of Structural Materials By X-Ray Technique

Archives of Metallurgy and Materials, 2015
The article presents the results of residual stress analysis in selected metal-metal joints manufactured by conventional welding and explosive merging. The X-ray diffraction technique applied for advanced stress-texture measurements and data processing ...
Bonarski J.T., Kania B., Bolanowski K., Karolczuk A.   +3 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Integrating Self-Organizing Map and Principal Component Analysis for Enhanced Herbal Leaf Image Classification [PDF]

BIO Web of Conferences
This study presents a classification model for herbal leaf images by combining Principal Component Analysis (PCA) for dimensionality reduction with Self-Organizing Map (SOM) as an unsupervised classification algorithm.
Ahmad Imam, Jusman Yessi, Rahmanto Yuri, Putrawansyah Ferry, Borman Rohmat Indra   +4 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source