Results 91 to 100 of about 2,685,361 (289)

Epicyclic orbital oscillations in Newton's and Einstein's dynamics

open access: yes, 2002
We apply Feynman's principle, ``The same equations have the same solutions'', to Kepler's problem and show that Newton's dynamics in a properly curved 3-D space is identical with that described by Einstein's theory in the 3-D optical geometry of ...
M. A. Abramowicz   +9 more
core   +2 more sources

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Test particles behavior in the framework of a lagrangian geometric theory with propagating torsion

open access: yes, 2003
Working in the lagrangian framework, we develop a geometric theory in vacuum with propagating torsion; the antisymmetric and trace parts of the torsion tensor, considered as derived from local potential fields, are taken and, using the minimal action ...
Cartan É.   +16 more
core   +2 more sources

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Examining Pancasila’s Position in the Public Reason Scheme: A Critical Analysis

open access: yesJurnal Politik, 2019
This research tries to review a number of ideas of some Indonesian scholars such as Yudi Latif, Franz Magnis-Suseno, and Syamsul Ma'arif, who saw and described the relationship between Pancasila and public reason, one of the popular political concepts in
Muhamad Iswardani Chaniago
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Public Legal Reason [PDF]

open access: yes, 2006
This essay develops an ideal of public legal reason--a normative theory of legal reasons that is appropriate for a society characterized by religious and moral pluralism.
Solum, Lawrence B.
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Holography, charge and baryon asymmetry

open access: yes, 2012
The reason for baryon asymmetry in our universe has been a pertinent question for many years. The holographic principle suggests a charged preon model underlies the Standard Model of particle physics and any such charged preon model requires baryon ...
Mongan, T. R.
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

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