Results 81 to 90 of about 166,272,513 (247)

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

The principle of goodness and reality situating a fundamental ethical principle [PDF]

, 2005
This paper describes an ethical theory provisionally called the Principle of Goodness. Before doing so, however, it is necessary to discuss the nature of human beliefs in general, in order to correctly situate the theory.
House, Ron
core   +1 more source

Reinterpreting Schopenhauer’s Fourfold Root: Causality, Immanence, and the Limits of Metaphysical Explanation

Philosophies
Background: Arthur Schopenhauer’s On the Fourfold Root of the Principle of Sufficient Reason (in its revised 1847 edition) has been variously interpreted as an epistemological prelude to his metaphysics of will, as a continuation of Kantian ...
Jan Kerkmann
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Postmodernity and its Archive. The Principle of Insufficient Reason Revisited

, 2001
In this essay, I discuss two major theoretical discourses of modernity, namely, of classical modernity and postmodernity. Moreover, I aim at a proposition of a possible historical relation between those two discourses of crucial importance to modernity’s
Isenberg, Bo,, Lund University.
core  

Probabilistic and Geometric Languages in the Context of the Principle of Least Action [PDF]

, 2012
This paper explores the question of the unification of the three basic languages of physics, the geometric language of forces, the geometric language of fields or 4-dimensional space-time, and the probabilistic language of quantum mechanics.
Terekhovich, Vladislav E.
core  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Antinomies and the Principle of Sufficient Reason [PDF]

, 2002
As concerns proofs of "Transcendental Antinomies" in the Critique of Pure Reason, it has been quite a natural attitude to entertain doubts against their validity. This paper picks up some proofs from both Theses and Antitheses of the Antinomies and tries
長田, 蔵人
core  

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source