Results 61 to 70 of about 166,272,513 (247)
The Principal Principle Implies the Principle of Indifference [PDF]
, 2015 We argue that David Lewis’s principal principle implies a version of the principle of indifference. The same is true for similar principles that need to appeal to the concept of admissibility. Such principles are thus in accord with objective Bayesianism,
Wallmann, Christian +7 more
core +1 more source
How Did Leibniz’s God Create the World?
Journal of Modern PhilosophyI show that Leibniz’s account of divine concurrence is constrained in a surprising way by his commitment to the Principle of Sufficient Reason, where a sufficient reason for the existence of an entity or a state of affairs is understood to be the ...
Fatema Amijee
doaj +2 more sources
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source
Physics and the Principle of Sufficient Reason [PDF]
The Principle of Sufficient Reason (PSR) holds that, for everything that exists or occurs or holds true, there is a reason why that is the case. I consider three possible ways of relating physics to the PSR: past states as reasons for present states ...
Carroll, Sean M.
core +2 more sources
Pattimura Legal JournalIntroduction: Business competition often drives companies to engage in unfair practices, including violations of the rule of reason principle, where market dominance is achieved through cartel-like behavior.
Maudy Miranda +2 more
doaj +1 more source
‘Abstract Endangerment’, Two Harm Principles, and Two Routes to Criminalisation
Bergen Journal of Criminal Law and Criminal Justice, 2015 We need to distinguish, as theorists too often fail to distinguish, two distinct harm principles. One, the Harmful Conduct Principle, concerns the criminalisation of conduct that is itself harmful or dangerous: that principle cannot explain how we can ...
R.A. Duff, S.E. Marshall
doaj +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Determinism, "Ought" Implies "Can" and Moral Obligation
Dialectica, 2020 Haji argues that determinism threatens deontic morality, not via a threat to moral responsibility, but directly, because of the principle that "ought" implies "can".
Nadine Elzein
doaj +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
The principle of legal certainty as a principle of economic efficiency
, 2014 Legal certainty, a feature of the rule of law, constitutes a requirement for the operational necessities of market interactions. But, the compatibility of the principle of legal certainty with ideals such as liberalism and free market economy must not ...
Gough, Orla +5 more
core +1 more source