Results 71 to 80 of about 2,685,361 (289)

God’s Role in a Meaningful Life: New Reflections from Tim Mawson [PDF]

, 2018
Characteristic of the contemporary field of life's meaning has been the combination of monism in method and naturalism in substance. That is, much of the field has sought to reduce enquiry into life's meaning to one question and to offer a single ...
Metz, Thaddeus
core  

What Are the Odds that Everyone is Depraved? [PDF]

, 2020
Why does God allow evil? One hypothesis is that God desires the existence and activity of free creatures but He was unable to create a world with such creatures and such activity without also allowing evil. If Molinism is true, what probability should be
Hill, Scott
core  

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Critique of the One Reason. On the Systemic Unity of the Three ‘Critiques’

RUDN Journal of Philosophy
There is still disagreement among researchers about the question of the intention, unity and coherence of Kant's philosophy. In view of the distance in time to Kant, this state of affairs is as surprising as it is unsatisfactory.
Martin Bunte
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Reasoning with principles

Expert Systems with Applications, 2022
Tomasz Zurek, Michal Araszkiewicz, Dorota Stachura-Zurek   +2 more
openaire   +2 more sources

Application of the Principle Rule of Reason to the Determination of Airline Ticket Prices in Business Competition Practices

Pattimura Legal Journal
Introduction: Business competition often drives companies to engage in unfair practices, including violations of the rule of reason principle, where market dominance is achieved through cartel-like behavior.
Maudy Miranda, Elisatris Gultom, Deviana Yuanitasari   +2 more
doaj   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

‘Abstract Endangerment’, Two Harm Principles, and Two Routes to Criminalisation

Bergen Journal of Criminal Law and Criminal Justice, 2015
We need to distinguish, as theorists too often fail to distinguish, two distinct harm principles. One, the Harmful Conduct Principle, concerns the criminalisation of conduct that is itself harmful or dangerous: that principle cannot explain how we can ...
R.A. Duff, S.E. Marshall
doaj   +1 more source