Results 51 to 60 of about 299,806 (256)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Critique of the One Reason. On the Systemic Unity of the Three ‘Critiques’
RUDN Journal of PhilosophyThere is still disagreement among researchers about the question of the intention, unity and coherence of Kant's philosophy. In view of the distance in time to Kant, this state of affairs is as surprising as it is unsatisfactory.
Martin Bunte
doaj +1 more source
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
How Did Leibniz’s God Create the World?
Journal of Modern PhilosophyI show that Leibniz’s account of divine concurrence is constrained in a surprising way by his commitment to the Principle of Sufficient Reason, where a sufficient reason for the existence of an entity or a state of affairs is understood to be the ...
Fatema Amijee
doaj +2 more sources
‘Abstract Endangerment’, Two Harm Principles, and Two Routes to Criminalisation
Bergen Journal of Criminal Law and Criminal Justice, 2015 We need to distinguish, as theorists too often fail to distinguish, two distinct harm principles. One, the Harmful Conduct Principle, concerns the criminalisation of conduct that is itself harmful or dangerous: that principle cannot explain how we can ...
R.A. Duff, S.E. Marshall
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Pattimura Legal JournalIntroduction: Business competition often drives companies to engage in unfair practices, including violations of the rule of reason principle, where market dominance is achieved through cartel-like behavior.
Maudy Miranda +2 more
doaj +1 more source
Determinism, "Ought" Implies "Can" and Moral Obligation
Dialectica, 2020 Haji argues that determinism threatens deontic morality, not via a threat to moral responsibility, but directly, because of the principle that "ought" implies "can".
Nadine Elzein
doaj +1 more source