Results 41 to 50 of about 299,806 (256)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Localizing Violations of the Principle of Sufficient Reason—Leibniz on the Modal Status of the PSR

Journal of Modern Philosophy, 2022
The Principle of Sufficient Reason (PSR)—the principle that everything has a reason—plays a central role in Leibniz’s philosophical system. It is rather difficult, however, to determine what Leibniz’s attitude towards the modal status of the PSR is.
Sebastian Bender
doaj   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

The principle of solidarity between sentiment and reason: a reflection starting from L. Bourgeois’ solidarism.

Nordicum-Mediterraneum, 2023
The article traces the process that led to the shift of the concept of solidarity from the domain of feelings to political rationality. Going through the genealogy of the term, its polysemy emerges: from the juridical meaning to the sentiment, sense of ...
Paola de Cuzzani
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

A Comparative Study on the Degree of Dependence of Clarke’s and Sadra’s Arguments for the Existence of God on the Principle of Sufficient Reason [PDF]

حکمت و فلسفه, 2010
After briefly discussing the various versions of the Principle of Sufficient Reason (hereafter PSR), I argue that Clarke’s classic version of the Cosmological Arguments for the existence of God is rooted in the PSR, while Sadra’s so-called Siddigin ...
hasan hoseyni
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

HOW THE PRINCIPLE OF SUFFICIENT REASON UNDERMINES THE COSMOLOGICAL ARGUMENT

Kriterion
My aim here is to show how the Cosmological Argument (CA) is undermined by one of its own premises: the Principle of Sufficient Reason (PSR). Firstly, I explain the type of CA that I am thinking about (I).
Sebastián Briceño
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source