Results 31 to 40 of about 167,610,246 (239)
How Did Leibniz’s God Create the World?
Journal of Modern PhilosophyI show that Leibniz’s account of divine concurrence is constrained in a surprising way by his commitment to the Principle of Sufficient Reason, where a sufficient reason for the existence of an entity or a state of affairs is understood to be the ...
Fatema Amijee
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The notion of necessity in the German philosophy of the Enlightenment [PDF]
Кантовский сборник, 2014 Necessity is a key philosophical notion, which is used in different disciplines from logic to ontology. In the German philosophy of the Enlightenment, this concept was centralto the work of many thinkers.
Fetisova D.
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Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
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The PSR as a practical principle in Kantian ethics [PDF]
Belgrade Philosophical AnnualThe Principle of Sufficient Reason (PSR) is the canonical expression of the idea of reality as fundamentally rational or intelligible, such that there is always a sufficient ground or explanation for everything about which such questions can be asked. In
Schafer Karl
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FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Manuscrito, 2020 I discuss Paul Guyer’s contribution to the Cambridge Elements: The Philosophy of Immanuel Kant series. The author argues that Kant derives the fundamental principle and the object of morality from the fundamental principles of reason (the law of ...
VINICIUS CARVALHO
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Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source