Results 41 to 50 of about 167,610,246 (239)

Socrates, Vlastos, Scanlon and the Principle of the Sovereignty of Virtue

open access: yesArchai: Revista de Estudos sobre as Origens do Pensamento Ocidental, 2020
This article offers a new formulation of the Socratic principle known as the Principle of the Sovereignty of Virtue (PSV). It is divided in three sections. In the first section I criticize Vlastos’ formulation of the PSV.
Daniel Simão Nascimento
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

open access: yesFEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança   +2 more
wiley   +1 more source

Sufficient reason and reason enough [PDF]

open access: yes, 2015
I offer an analysis of the Principle of Sufficient Reason and its relevancy for the scientific endeavour. I submit that the world is not, and cannot be, rational—only some brained beings are.
Romero, Gustavo E.   +2 more
core   +1 more source

Alexander Baumgarten on the Principle of Sufficient Reason [PDF]

open access: yes, 2014
This paper defends the Principle of Sufficient Reason, taking Baumgarten as its guide. The primary aim is not to vindicate the principle, but rather to explore the kinds of resources Baumgarten originally thought sufficient to justify the PSR against its
Fugate, Courtney D.
core   +3 more sources

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Antinomies and the Principle of Sufficient Reason [PDF]

open access: yes, 2002
As concerns proofs of "Transcendental Antinomies" in the Critique of Pure Reason, it has been quite a natural attitude to entertain doubts against their validity. This paper picks up some proofs from both Theses and Antitheses of the Antinomies and tries
長田, 蔵人
core  

Reinterpreting Schopenhauer’s Fourfold Root: Causality, Immanence, and the Limits of Metaphysical Explanation

open access: yesPhilosophies
Background: Arthur Schopenhauer’s On the Fourfold Root of the Principle of Sufficient Reason (in its revised 1847 edition) has been variously interpreted as an epistemological prelude to his metaphysics of will, as a continuation of Kantian ...
Jan Kerkmann
doaj   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

open access: yesFEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Retrocausal Effects as a Consequence of Quantum Mechanics Refined to Accommodate the Principle of Sufficient Reason [PDF]

open access: yes, 2011
The principle of sufficient reason asserts that anything that happens does so for a reason: no definite state of affairs can come into being unless there is a sufficient reason why that particular thing should happen. This principle is usually attributed
Daniel P. Sheehan   +2 more
core   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

open access: yesFEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

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