Results 61 to 70 of about 167,610,246 (239)
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Leibniz And Hegel: On The Question Of The Principles Of The Sufficient Reason And The Identity
Aufklärung, 2015 This article attempts to bring some questions proposed by Hegel on the philosophy of Leibniz, in view of the considerations of this with respect to Principles of Philosophy or Monadology.
Cristiano Bonneau
doaj +3 more sources
Leibniz and the Principle of Sufficient Reason [PDF]
, 2018 Leibniz’s principle of sufficient reason (PSR) is the claim that everything has an explanation. It rules out brute facts, inexplicable primitives, and purely random events. On the usual view, Leibniz grounds the PSR in purely descriptive truths.
Pikkert, Owen
core +1 more source
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
The Principle of Sufficient Reason: A Moral Argument [PDF]
, 1996 The Clarke/Rowe version of the Cosmological Argument is sound only if the Principle of Sufficient Reason (PSR) is true, but many philosophers, including Rowe, think that there is not adequate evidence for the principle of sufficient reason.
Nelson, Mark T.
core
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
Something, nothing and Leibniz’s question. negation in logic and metaphysics
Studies in Logic, Grammar and Rhetoric, 2018 This paper discusses the concept of nothing (nothingness) from the point of logic and ontology (metaphysics). It is argued that the category of nothing as a denial of being is subjected to various interpretations.
Woleński Jan
doaj +1 more source
Schopenhauer on space, time, causality and matter: a physical reexamination
Voluntas, 2019 According to Schopenhauer, Kant’s arguments about the transcendental ideality of space and time have implications for matter through the concept of causality and the principle of sufficient reason.
Shahen Hacyan
doaj +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source