Results 51 to 60 of about 167,610,246 (239)
Schopenhauer on the Principle of Sufficient Reason
, 1971 ‘The Principle of Sufficient Reason in all its forms is the sole principle and the sole support of all necessity. For necessity has no other true and distinct meaning than that of the infallibility of the consequence when the reason is posited ...
D. W. Hamlyn
core +1 more source
El principio de razón suficiente
Scientia et Fides, 2015 The Principle of Sufficient ReasonAccording to Alexander R. Pruss the Principle of Sufficient Reason (PSR) is essential to solve two classical problems of philosophy: 1) the problem of infinite regress and 2) the non-emergence of entities ex nihilo ...
Rubén Pereda
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
On the Fourfold Root of the Principle of Sufficient Reason and on the Will in Nature [PDF]
, 1891 On the Fourfold Root of the Principle of Sufficient Reason is an elaboration on the classical Principle of Sufficient Reason written by German philosopher Arthur Schopenhauer as his doctoral dissertation in 1813.
Schopenhauer, Arthur, Hillebrand, Karl
core +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
On the Principle of Sufficient Reason [PDF]
, 2006 The aim of this paper is to defend the Principle of Sufficient Reason (PSR). I analyse various versions of this principle (and their structure) and various ways of justifying it.
Wojtysiak, Jacek
core
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
The Principle of Sufficient Reason and Free Will [PDF]
, 2019 I examine Leibniz’s version of the Principle of Sufficient Reason with respect to free will, paying particular attention to Peter van Inwagen’s argument that this principle leads to determinism.
McAllister, Blake
core
On Some Leibnizian Arguments for the Principle of Sufficient Reason [PDF]
, 2020 Leibniz often refers to the Principle of Sufficient Reason (PSR) as something like a first principle. In some texts, however, he attempts to give positive arguments in its favor. I examine two such arguments, and find them wanting. The first argument has
Harrop, Stephen
core +2 more sources