Results 51 to 60 of about 135,510 (251)
SUFFICIENT REASON AND THE CAUSAL ARGUMENT FOR MONISM [PDF]
Societate şi Politică, 2011 What is the role of the principle of sufficient reason inBaruch Spinoza’s ontological proof for God’s existence? Is this roleidentical within Spinoza’s early work on method, the Treatise on theEmendation of the Intellect, and his magnum opus, the Ethics?
Landon FRIM
doaj
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Leibniz And Hegel: On The Question Of The Principles Of The Sufficient Reason And The Identity
Aufklärung, 2015 This article attempts to bring some questions proposed by Hegel on the philosophy of Leibniz, in view of the considerations of this with respect to Principles of Philosophy or Monadology.
Cristiano Bonneau
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Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
The Principle of Sufficient Reason in Spinoza [PDF]
, 2013 This chapter investigates Spinoza’s commitment to the Principle of Sufficient Reason (the PSR) and its role in his system. What sorts of things does Spinoza think require a cause or explanation? What counts, for him, as a cause or explanation? The PSR is often associated with doctrines such as necessitarianism, the Principle of the Identity of ...
openaire +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Something, nothing and Leibniz’s question. negation in logic and metaphysics
Studies in Logic, Grammar and Rhetoric, 2018 This paper discusses the concept of nothing (nothingness) from the point of logic and ontology (metaphysics). It is argued that the category of nothing as a denial of being is subjected to various interpretations.
Woleński Jan
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Schopenhauer on space, time, causality and matter: a physical reexamination
Voluntas, 2019 According to Schopenhauer, Kant’s arguments about the transcendental ideality of space and time have implications for matter through the concept of causality and the principle of sufficient reason.
Shahen Hacyan
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