Results 91 to 100 of about 67,311 (287)

Rapid generation of prion disease models using AAV‐delivered PrP variants in knockout mice

Brain Pathology, EarlyView.
We developed a rapid AAV‐based system to generate prion disease models in weeks rather than months. Following systemic AAV9P31 delivery of modified PrP to knockout mice, we achieved brain‐wide expression and successful propagation of both classical (RML) and atypical (GSS‐A117V) prion strains.
Maitena San‐Juan‐Ansoleaga, Eva Fernández‐Muñoz, Jorge M. Charco, Enric Vidal, Diego Herrero‐Martínez, Josu Galarza‐Ahumada, Cristina Sampedro‐Torres‐Quevedo, Samanta Giler, Mariví Geijo, Gloria González‐Aseguinolaza, Hasier Eraña, Joaquín Castilla   +11 more
wiley   +1 more source

Letter to the Editor Regarding Kortazar‐Zubizarreta et al. ‘The Risk of Transmission of Genetic Prion Diseases Is Greater Than 50%’ [PDF]

Eur J Neurol
European Journal of Neurology, Volume 33, Issue 3, March 2026.
Nihat A, Mok T, Minikel E, Collinge J, Mead S.   +4 more
europepmc   +2 more sources

Development and usefulness of new polymerase chain reaction-based tests for detection of different alleles at codons 136 and 171 of the ovine prion protein gene [PDF]

, 1999
Vilma Yuzbasiyan‐Gurkan, Janver D. Krehbiel, Yueying Cao, Patrick J. Venta   +3 more
openalex   +1 more source

The L108I polymorphism in mouse prion protein drives spontaneous disease and enhances transmission of atypical and classical prion strains

Brain Pathology, EarlyView.
A single amino acid change (L108I) combined with PrP overexpression drives spontaneous atypical prion formation in mice, enabling also efficient propagation of diverse prion strains. This model allows studying how spontaneous prion diseases arise and provides powerful tools for investigating strain emergence, transmission barriers, and mechanisms ...
Hasier Eraña, Enric Vidal, Natalia Fernández‐Borges, Jorge M. Charco, Carlos M. Díaz‐Domínguez, Cristina Sampedro‐Torres‐Quevedo, Josu Galarza‐Ahumada, Eva Fernández‐Muñoz, Maitena San‐Juan‐Ansoleaga, Miguel Ángel Pérez‐Castro, Nuno Gonçalves‐Anjo, Patricia Piñeiro, Samanta Giler, Nora González‐Martín, Nuria L. Lorenzo, Africa Manero‐Azua, Guiomar Perez de Nanclares, Mariví Geijo, Manuel A. Sánchez‐Martín, Jesús R. Requena, Joaquín Castilla   +20 more
wiley   +1 more source

Overlap of nonbreeding wandering albatrosses with fisheries and implications for colony‐specific population trajectories at South Georgia

Conservation Biology, EarlyView.
Abstract Bycatch in fisheries is one of the most serious threats to pelagic seabirds, causing major population declines. Mitigation measures can reduce bycatch substantially, but many fisheries fail to apply best practices, and seabird mortality remains high.
V. Warwick‐Evans, E. J. Pearmain, R. A. Phillips   +2 more
wiley   +1 more source

Prions–New Infectious Agents [PDF]

, 2000
Jack L. Pulec
openalex   +1 more source

BOLL‐Containing Aggregates Mediate the Translational Regulation During Human Oogenesis

Cell Proliferation, EarlyView.
This work elucidates that BOLL‐containing aggregate‐mediated translational control is essential for human oogenesis. These aggregates recruit PABPC1 and FXR1 to activate the translation of U‐rich mRNAs encoding cell cycle proteins, thereby ensuring successful meiotic progression.
Ying Li, Lingya Mao, Boyuan Liang, Longxin Xie, Wenpei Xiang, Kehkooi Kee   +5 more
wiley   +1 more source

Transmissible Spongiform Encephalopathies Prion Proteins: A Systematic Review

, 2023
Anirban Poddar, Tiyasha Kundu, Manaly Sinha Ray, Rituparna Maji   +3 more
openalex   +2 more sources

Assessment of land‐based threats to Atlantic pelagic seabirds

Conservation Science and Practice, EarlyView.
Highly mobile pelagic seabirds face numerous land‐based threats during their breeding seasons, including invasive alien species, climate change, and diseases, which drive population declines. Using field expertise and a literature review, we collated a dataset assessing 18 threats affecting 49 species across 38 Atlantic Large Marine Ecosystems. We used
Ioannis Kalaitzakis, Ana S. L. Rodrigues, Maria P. Dias, Tammy E. Davies, Mark A. Baran, Nina Bhola, Thierry Boulinier, Joël Bried, Letizia Campioni, Filipe R. Ceia, Federico De Pascalis, Nina Dehnhard, Ana Isabel Fagundes, Olivier Gilg, Jacob González‐Solís, David Grémillet, Marcos Hernández‐Montero, Lucas Krüger, Amanda Kuepfer, Heather L. Major, Mark L. Mallory, Teresa Militão, Nuno Oliveira, Steffen Oppel, Vitor H. Paiva, Jorge M. Pereira, Richard A. Phillips, Ingrid L. Pollet, Aurore Ponchon, Andre F. Raine, Raül Ramos, Jaime A. Ramos, Gregory J. Robertson, Diego Vicente Sastre, Dave Shutler, Mónica C. Silva, Sarah Wanless, Marco Zenatello, Marie‐Morgane Rouyer   +38 more
wiley   +1 more source

Functional amyloid protein FXR1 is recruited into neuronal stress granules

Prion
The FXR1 protein regulates the stability and translation of a number of RNA molecules and plays an important role in the regulation of cellular processes under normal conditions and stress.
Anna A. Valina, Tatyana A. Belashova, Anastasia K. Yuzman, Sergey P. Zadorsky, Evgeniy I. Sysoev, Vladimir A. Mitkevich, Alexander A. Makarov, Alexey P. Galkin   +7 more
doaj   +1 more source