Results 101 to 110 of about 75,780 (211)

Swine influenza A replicon particle and live attenuated influenza virus vaccines induce differential systemic and mucosal antibody and T cell responses

Frontiers in Veterinary Science
Influenza A virus (IAV) in swine is a significant economic concern, and there is a critical need to improve vaccine efficacy. Commercial and experimental vaccine platforms are effective against homologous infection but may not reliably provide protection
Meghan Wymore Brand, Bryan S. Kaplan, Carine K. Souza, Jayne E. Wiarda, J. Brian Kimble, Bailey Arruda, Daniel R. Perez, Amy L. Baker   +7 more
doaj   +1 more source

Silent Prions and Covert Prion Transmission

PLOS Pathogens, 2015
Prions are infectious agents with zoonotic potential that cause progressive neurodegenerative diseases, known as the transmissible spongiform encephalopathies (TSEs), in animals and humans. Prion disease can be initiated by a spontaneous event, handed down within families from generation to generation through genetic inheritance, or transmitted between
openaire   +4 more sources

Genetic assessment of apolipoprotein E polymorphism and PRNP genotypes in rapidly progressive dementias in Pakistan

Prion
Rapidly progressive dementias (RPDs) are a type of fatal dementias that cause rapid progression of neuronal dysfunction. This study aimed to assess the prevalence of APOE genotypes (ε2, ε3, ε4) and PRNP mutations (E200K, M129V) in the general population ...
Urwah Rasheed, Minahil Khalid, Aneeqa Noor, Umar Saeed, Rizwan Uppal, Saima Zafar   +5 more
doaj   +1 more source

Change in tau phosphorylation associated with neurodegeneration in the ME7 model of prion disease

, 2010
Hyperphosphorylation of the microtubule-associated protein tau is a significant determinant in AD (Alzheimer's disease), where it is associated with disrupted axonal transport and probably causes synaptic dysfunction.
Perry, V. Hugh, O'Connor, Vincent, Asuni, Ayodeji A.   +2 more
core   +1 more source

Prions and prion diseases [PDF]

The FEBS Journal, 2007
openaire   +2 more sources

Chronic Wasting Disease Research in North America: A systematic review highlighting species-wise and interdisciplinary research trends

Prion
Chronic Wasting Disease (CWD) research has experienced significant growth, spanning diverse disciplines such as genetics, immunology, modelling, and behaviour.
Chandika RG, Anaïs Tallon, Emily K. Latch   +2 more
doaj   +1 more source

Differential pathology of P102L-associated Gerstmann–Stäussler–Scheinker disease: exclusive presence of 8-kDa protease-resistant prion protein vs. co-existence of 8-kDa and type-1 protease-resistant prion protein, with a focus on codon 129 polymorphism

Prion
Gerstmann – Sträussler – Scheinker disease (GSS) is a hereditary prion disease characterized by clinicopathological heterogeneity. In Japan, the most common mutation is P102L, typically associated with prion protein (PrP) plaques, spongiform changes, and
Hideko Noguchi, Motoi Yoshimura, Akihiro Watanabe, Sachiko Koyama, Naonori Sakurada, Masahiro Shijo, Takaaki Kanemaru, Keita Kai, Shinichi Aishima, Haruki Koike, Yoshio Tsuboi, Naokazu Sasagasako, Hiroyuki Honda   +12 more
doaj   +1 more source

Proteína prion celular (PrPc) altera a suscetibilidade ao etanol através da modulação do sistema dopaminérgico [PDF]

, 2013
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em FarmacologiaO consumo de drogas com potencial aditivo, como o etanol, induz alterações sinápticas profundas na via mesocorticolímbica ...
Rial, Daniel
core  

Specific early electroencephalogram for the diagnosis of sporadic Creutzfeldt-Jakob disease

Prion
An early diagnosis is required for intervention in prion disease cases. To elucidate the specificity of early electroencephalography discharges in cases of sporadic Creutzfeldt-Jakob disease, we analysed epileptiform discharges through ...
Taiki Matsubayashi, Hirokazu Natsui, Katsuya Satoh, Tetsuyuki Kitamoto, Takanori Yokota, Nobuo Sanjo   +5 more
doaj   +1 more source

Prion and Prion Diseases

, 2020
This review article provides the main information regarding a specific category of infectious diseases of animals and humans, the so-called transmissible spongiform encephalopathies, or prion infections. In a brief introduction explains the need for lighting issues in relation to environmental, veterinary public health importance in traffic and the ...
openaire   +1 more source