Results 91 to 100 of about 75,780 (211)

Dissection and design of yeast prions. [PDF]

, 2004
Many proteins can misfold into beta-sheet-rich, self-seeding polymers (amyloids). Prions are exceptional among such aggregates in that they are also infectious.
Cox Brian S, Lev Z Osherovich (26522), Lev Z Osherovich, Cox, Brian S., Mick F Tuite, Brian S Cox (26523), Osherovich Lev Z, Tuite, Mick F., Osherovich, Lev Z., Jonathan S Weissman (23734), Brian S Cox, Mick F Tuite (26524), Jonathan S Weissman, Weissman, Jonathan S., Tuite Mick F, Weissman Jonathan S   +15 more
core   +2 more sources

Correction. [PDF]

Prion
europepmc   +2 more sources

Genetic Variation and Strain Dynamics in Chronic Wasting Disease

Viruses
Chronic wasting disease (CWD) is a prion disease of cervids marked by growing strain diversity and variation in host susceptibility. Central to this complexity are prion protein gene (Prnp) polymorphisms, which can modulate pathogenesis by altering the ...
Irina Zemlyankina, Melissa Razcon-Echeagaray, Gokhan Yilmaz, Kristen B. Gregg, Sabine Gilch, Samia Hannaoui   +5 more
doaj   +1 more source

Aqueous extraction of formalin-fixed paraffin-embedded tissue and detection of prion disease using real-time quaking-induced conversion

BMC Research Notes
Objective The goal of the research presented here is to determine if methods previously developed for the aqueous extraction of PrPSc from formalin-fixed paraffin-embedded tissue (FFPET) are applicable to the detection PrPSc by real-time quaking induced ...
Eric M. Nicholson, Justin J. Greenlee, Soyoun Hwang   +2 more
doaj   +1 more source

Analysis of the hippocampal proteome in ME7 prion disease reveals a predominant astrocytic signature and highlights the brain-restricted production of clusterin in chronic neurodegeneration

, 2014
Prion diseases are characterized by accumulation of misfolded protein, gliosis, synaptic dysfunction, and ultimately neuronal loss. This sequence, mirroring key features of Alzheimer disease, is modeled well in ME7 prion disease.
Asuni, Ayodeji A, Skipp, Paul, Gray, Bryony, Bailey, Joanne, O'Connor, Vincent, Perry, V Hugh   +5 more
core   +1 more source

Update on human prion disease [PDF]

, 2007
The recognition that variant Creutzfeldt–Jakob disease (vCJD) is caused by the same prion strain as bovine spongiform encephalopathy in cattle has dramatically highlighted the need for a precise understanding of the molecular biology of human prion ...
Wadsworth, Jonathan D.F., Collinge, John
core   +1 more source

Identifying molecular determinants of prion conversion [PDF]

, 2017
Prion diseases have been widely studied, but despite many great leaps in our knowledge of prion and protein misfolding diseases in general, many gaps remain. One example is the structural triggers or provocators of prion conversion found within the prion
Pischke, Kate Elizabeth
core  

Synthesis and structural characterization of a mimetic membrane-anchored prion protein [PDF]

, 2006
During pathogenesis of transmissible spongiform encephalopathies (TSEs) an abnormal form (PrPSc) of the host encoded prion protein (PrPC) accumulates in insoluble fibrils and plaques. The two forms of PrP appear to have identical covalent structures, but
Hicks, M R, David H. Crout, Crout, D H, Teresa J. T. Pinheiro, Ian D. Sylvester, Andrew C. Gill, Imanpreet K. Bath, Atvinder K. Rullay, Gill, A C, Bath, I K, Pinheiro, T J T, Matthew R. Hicks, Sylvester, I D, Rullay, A K   +13 more
core   +1 more source

Single-cell transcriptomics unveils molecular signatures of neuronal vulnerability in a mouse model of prion disease that overlap with Alzheimer’s disease

Nature Communications
Understanding why certain neurons are more sensitive to dysfunction and death caused by misfolded proteins could provide therapeutically relevant insights into neurodegenerative disorders.
Jessy A. Slota, Lise Lamoureux, Kathy L. Frost, Babu V. Sajesh, Stephanie A. Booth   +4 more
doaj   +1 more source

Decontamination of prions, prion-associated amyloid and inefectivity from surgical stainless steel - implications for the risk of iatrogenic transmission of CJD

, 2009
The physicochemical nature of the infectious agent in prion diseases creates asignificant challenge for decontamination services. It has been shown to be both resistant tostandard methods of decontamination, used to inactivate viruses and bacteria, and ...
Howlin, Robert
core   +1 more source