Results 71 to 80 of about 75,780 (211)

Endogenous Viral Etiology of Prion Diseases [PDF]

, 2009
Transmissible spongiform encephalopathies (TSEs), or prion diseases, are a group of incurable neurodegenerative disorders, including Kuru and Creutzfeldt-Jakob disease in humans, “mad cow” disease in cattle, and scrapie in sheep. This paper
Claudiu I. Bandea
core  

Prion Protein Scrapie and the Normal Cellular Prion Protein

, 2015
Prions are infectious proteins and over the past few decades, some prions have become renowned for their causative role in several neurodegenerative diseases in animals and humans.
Munn, Alan L, Atkinson, Caroline, Wiegmans, Adrian, Munn, Alan, Wei, Ming, Wei, Ming Q, Zhang, Kai, Atkinson, Caroline J   +7 more
core   +1 more source

Pathologic and biochemical characterization of PrPSc from elk with PRNP polymorphisms at codon 132 after experimental infection with the chronic wasting disease agent

BMC Veterinary Research, 2018
Background The Rocky Mountain elk (Cervus elaphus nelsoni) prion protein gene (PRNP) is polymorphic at codon 132, with leucine (L132) and methionine (M132) allelic variants present in the population.
S. Jo Moore, Catherine E. Vrentas, Soyoun Hwang, M. Heather West Greenlee, Eric M. Nicholson, Justin J. Greenlee   +5 more
doaj   +1 more source

SERPINA3/SerpinA3n: a novel promising therapeutic target in prion diseases [PDF]

, 2021
Prion diseases, also known as transmissible spongiform encephalopathies (TSEs), belong to a class of fatal neurodegenerative disorders characterized by vacuolation and neuronal loss in the brain paralleled by cognitive and motor impairments.
Colini Baldeschi, Arianna
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Prion and prion-like diseases in animals

Virus Research, 2015
Transmissible spongiform encephalopaties (TSEs) are fatal neurodegenerative diseases characterized by the aggregation and accumulation of the misfolded prion protein in the brain. Other proteins such as β-amyloid, tau or Serum Amyloid-A (SAA) seem to share with prions some aspects of their pathogenic mechanism; causing a variety of so called prion-like
Aguilar-Calvo, Patricia, García, Consolación, Carlos Espinosa, Juan, Andréoletti, Olivier, Mariá Torres, Juan   +4 more
openaire   +4 more sources

Palliative care symptoms of people living with rapidly progressive prion diseases: a systematic review

BMC Palliative Care
Background Creutzfeldt-Jakob disease (CJD) is a rapidly progressive, fatal dementia with an average prognosis of four to six months. Palliative care, as a holistic person-centred approach to supporting people and families affected by life-limiting ...
Rachel T. Williams, Nicola White, Joshua Kearns, Kirsty McNiven, Ann Rochelle Marasigan, Elizabeth L. Sampson, Catherine J. Evans, Simon Mead, Nuriye Kupeli, the EMBED‐Care Programme   +9 more
doaj   +1 more source

Detection of chronic wasting disease prions in soil at an illegal white-tailed deer carcass disposal site

Prion
Chronic wasting disease (CWD) is a contagious prion disorder affecting cervids such as deer, elk, caribou, and moose, causing progressive and severe neurological degeneration followed by eventual death.
Madeline K. Grunklee, Stuart S. Lichtenberg, Nicole A. Lurndahl, Marc D. Schwabenlander, Diana L. Karwan, E. Anu Li, Jason C. Bartz, Qi Yuan, Peter A. Larsen, Tiffany M. Wolf   +9 more
doaj   +1 more source

ApoE4 lowers age at onset in patients with frontotemporal dementia and tauopathy independent of amyloid‐β copathology

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2019
Introduction Apolipoprotein E (ApoE) is the most important genetic risk factor for Alzheimer's disease (AD), with ApoE4 thought to enhance and accelerate amyloid‐β (Aβ) pathology. ApoE4 has recently been described to increase neurodegeneration in a mouse
Carolin Koriath, Tammaryn Lashley, William Taylor, Ronald Druyeh, Athanasios Dimitriadis, Nicola Denning, Julie Williams, Jason D. Warren, Nick C. Fox, Jonathan M. Schott, James B. Rowe, John Collinge, Jonathan D. Rohrer, Simon Mead   +13 more
doaj   +1 more source

Porcine prion protein amyloid

, 2015
Mammalian prions are composed of misfolded aggregated prion protein (PrP) with amyloid-like features. Prions are zoonotic disease agents that infect a wide variety of mammalian species including humans.
Nyström, Sofie,, Hammarström, Per,
core   +1 more source

Raman optical activity demonstrates poly(L-proline) II helix in the N-terminal region of the ovine prion protein: Implications for function and misfunction [PDF]

, 2004
The aqueous solution structure of the full-length recombinant ovine prion protein PrP25-233, together with that of the N-terminal truncated version PrP94-233, have been studied using vibrational Raman optical activity (ROA) and ultraviolet circular ...
Rhie, A G O, Nielsen, Kurt, Blanch, EW, Rhie, AGO, Gill, AC, Hope, James, Hecht, L, Gill, Andrew C., Gill, A C, Blanch, E W, Barron, Laurence D., Barron, L D, Nielsen, K, Hope, J, Hecht, Lutz, Barron, LD, Blanch, Ewan W., Rhie, Alexandre G. O., Rhie, Alexandre G O   +18 more
core   +1 more source