Results 51 to 60 of about 75,780 (211)

Genome-wide association study of behavioural and psychiatric features in human prion disease. [PDF]

, 2015
Prion diseases are rare neurodegenerative conditions causing highly variable clinical syndromes, which often include prominent neuropsychiatric symptoms.
Carswell, C, MacKay, A, Thompson, AG, Porter, MC, Rudge, P, Collinge, J, Lowe, J, Mead, S, Uphill, J, Lukic, A   +9 more
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The crystal structure of the globular domain of sheep prion protein [PDF]

, 2004
The prion protein PrP is a naturally occurring polypeptide that becomes transformed from a normal conformation to that of an aggregated form, characteristic of pathological states in fatal transmissible spongiform conditions such as Creutzfeld–Jacob ...
Vasisht N, Whyte, SM, Dodson EJ, Vasisht, N, Gill, A.C., Whyte, S.M., Dodson, G.G., Whyte, S M, Vasisht, N., Bayley, P M, Verma, C., Verma C, Gill, A C, Bayley, PM, Bayley, P.M., Whyte SM, Haire LF, Gill AC, Gill, AC, Bayley PM, Dodson, EJ, Haire, L.F., Dodson, GG, Dodson, E.J., Haire, L F, Verma, C, Haire, LF, Dodson, E J, Dodson, G G   +28 more
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Development of a sensitive cell culture system to assess prion infectivity and the efficacy of prion decontamination technologies

, 2012
Creutzfeldt-Jakob disease (CJD) can be iatrogenically transmitted during transplants, grafts and transfusions from CJD infected donors and also contaminated surgical instruments.
Secker, Thomas
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Characterization of the prion protein in relation to normal cellular function and in disease [PDF]

, 2012
Transmissible spongiform encephalopathies (TSEs), also known as prion diseases, are a group of rare and fatal neurodegenerative disorders that can affect both human and animals.
Wik, Lotta
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Characterisation and prion transmission study in mice with genetic reduction of sporadic Creutzfeldt-Jakob disease risk gene Stx6

Neurobiology of Disease
Sporadic Creutzfeldt-Jakob disease (sCJD), the most common human prion disease, is thought to occur when the cellular prion protein (PrPC) spontaneously misfolds and assembles into prion fibrils, culminating in fatal neurodegeneration.
Emma Jones, Elizabeth Hill, Jacqueline Linehan, Tamsin Nazari, Adam Caulder, Gemma F. Codner, Marie Hutchison, Matthew Mackenzie, Michael Farmer, Thomas Coysh, Michael Wiggins De Oliveira, Huda Al-Doujaily, Malin Sandberg, Emmanuelle Viré, Thomas J. Cunningham, Emmanuel A. Asante, Sebastian Brandner, John Collinge, Simon Mead   +18 more
doaj   +1 more source

Estimating sequence diversity of prion protein gene (PRNP) in Portuguese populations of two cervid species: red deer and fallow deer

Prion, 2023
Among the transmissible spongiform encephalopathies (TSEs), chronic wasting disease (CWD) in cervids is now a rising concern in wildlife within Europe, after the detection of the first case in Norway in 2016, in a wild reindeer and until June 2022 a ...
Jorge C. Pereira, Nuno Gonçalves-Anjo, Leonor Orge, Maria A. Pires, Sara Rocha, Luís Figueira, Ana C. Matos, João Silva, Paula Mendonça, Paulo Carvalho, Paula Tavares, Carla Lima, Anabela Alves, Alexandra Esteves, Maria L. Pinto, Isabel Pires, Adelina Gama, Roberto Sargo, Filipe Silva, Fernanda Seixas, Madalena Vieira-Pinto, Estela Bastos   +21 more
doaj   +1 more source

Effect of enzymatic deimination on the conformation of recombinant prion protein [PDF]

, 2009
Deimination is the post-translational conversion of arginine residues to citrulline. It has been implicated as a causative factor in autoimmune diseases such as multiple sclerosis and rheumatoid arthritis and more recently, as a marker of ...
Oxley, David, Meersman, Filip, Webster, Judith, Young, Duncan S., Dear, Denise V., Bronstein, Igor, Gill, Andy   +6 more
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Variability in prion protein genotypes by spatial unit to inform susceptibility to chronic wasting disease

Prion, 2022
Chronic wasting disease (CWD) is a fatal encephalopathy affecting North American cervids. Certain alleles in a host’s prion protein gene are responsible for reduced susceptibility to CWD.
Alberto F. Fameli, Jessie Edson, Jeremiah E. Banfield, Christopher S. Rosenberry, W. David Walter   +4 more
doaj   +1 more source

Prion interference with multiple prion isolates [PDF]

Prion, 2008
Co-inoculation of prion strains into the same host can result in interference, where replication of one strain hinders the ability of another strain to cause disease. The drowsy (DY) strain of hamster-adapted transmissible mink encephalopathy (TME) extends the incubation period or completely blocks the hyper (HY) strain of TME following intracerebral ...
Charles R, Schutt, Jason C, Bartz
openaire   +2 more sources

Prion degradation pathways: Potential for therapeutic intervention [PDF]

, 2015
Prion diseases are fatal neurodegenerative disorders. Pathology is closely linked to the misfolding of native cellular PrP(C) into the disease-associated form PrP(Sc) that accumulates in the brain as disease progresses. Although treatments have yet to be
McKinnon, C, Tabrizi, SJ, Goold, R
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