Results 1 to 10 of about 7,111 (134)

Aptamer-Targeted PrPC Drives Colorectal Cancer Metastasis via a LYN-STAT3 Complex and Enables Liquid Biopsy Detection. [PDF]

Adv Sci (Weinh)
The aptamer WHY‐3E identifies PrPC as a CRC driver. Stabilized by USP18, endocytosed PrPC forms a LYN/STAT3 complex, upregulating MSN transcription to promote metastasis. Crucially, WHY‐3E sensitively detects PrPC‐positive circulating exosomes, establishing a robust theoretical foundation for non‐invasive clinical diagnostics.
Wang C, Wu H, Zheng C, Zhang H, Wu X, Wang J, Chang Z, Xiang J, Liu Y, Zhang C, Wang Y, Jiang H, Zhong Y, Luo J, Chen Y, Zhang N, Zhang W, Yuan Z, Zou C, Tan W, Wang M, Hu H, Bing T, Wang G.   +23 more
europepmc   +2 more sources

Cellular prion protein and its derived peptides: multifaceted roles in neurodegenerative diseases and potential as biomarkers. [PDF]

Cell Biosci
Neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), and transmissible spongiform encephalopathies (TSEs), share fundamental mechanisms of protein misfolding, synaptic dysfunction, and ...
Mari E, Aventaggiato M, Paldino E, Ceccarelli S, Mucci N, Bellomo G, Mantuano E, Dugheri S, Martellucci S, Mattei V.   +9 more
europepmc   +2 more sources

Prnp Deletion Mitigates Muscle Fiber Type-Specific Sarcopenia Induced by Prion Infection in Mice. [PDF]

Immun Inflamm Dis
ABSTRACT Recent studies have shown that significant expression of PrPC protein is also present in skeletal muscle, and it plays a significant role in maintaining skeletal muscle homeostasis. Although the expression of PrPC in skeletal muscle has been clarified, the effects of PrPSc‐mediated prion protein infection on sarcopenia in mice and its ...
Liu W, Kim YC, Won SY, Kieu TTT, Kook SH, Jeong BH, Kim SH.   +6 more
europepmc   +2 more sources

Exploring and Targeting the Connection of Iron and Copper Homeostasis to Neurodegenerative Diseases. [PDF]

MedComm (2020)
Iron and copper dyshomeostasis, along with their interactions with key intrinsically disordered proteins (e.g., Aβ, tau, α‐synuclein) have a strong implication in the onset and progression of neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), Prion diseases (PrDs), Huntington's disease (HD), Wilson's disease (WD),
Liu X, Jia L, Wu K, Chen M, Sun J, Yang C, Xu C, Sun J, Wang J, Dai L.   +9 more
europepmc   +2 more sources

Novel anti-prion compounds screening in prion-infected cell culture model combined with surface plasmon resonance analysis. [PDF]

Sci Rep
Prions are misfolded proteins (PrPSc) capable of inducing the same conformational change in normal prion proteins (PrPC). These aberrant proteins are responsible for neurodegenerative diseases in animals and humans, for which no effective treatments ...
Hazekawa M, Ishibashi D, Altieri A, Spiridonov EA, Dmitriev NA, Lukyanenko ER, Biasini E, Kurkin AV.   +7 more
europepmc   +2 more sources

The Expression of Cellular Prion Protein, PrPC, Favors pTau Propagation and Blocks NMDAR Signaling in Primary Cortical Neurons

Cells, 2023
Background: The N-methyl-D-aspartate receptor (NMDAR) is a target in current treatments for Alzheimer’s disease (AD). The human prion protein (PrPC) has an important role in the pathophysiology of AD.
Rafael Rivas-Santisteban, Iu Raïch, David Aguinaga, Carlos A. Saura, Rafael Franco, Gemma Navarro   +5 more
doaj   +1 more source

Copper and Zinc Interactions with Cellular Prion Proteins Change Solubility of Full-Length Glycosylated Isoforms and Induce the Occurrence of Heterogeneous Phenotypes. [PDF]

PLoS ONE, 2016
Prion diseases are characterized biochemically by protein aggregation of infectious prion isoforms (PrPSc), which result from the conformational conversion of physiological prion proteins (PrPC).
Svetlana Brim, Martin H Groschup, Thorsten Kuczius   +2 more
doaj   +1 more source

Inducing prion protein shedding as a neuroprotective and regenerative approach in pathological conditions of the brain: from theory to facts

Neural Regeneration Research, 2023
In the last decades, the role of the prion protein (PrP) in neurodegenerative diseases has been intensively investigated, initially in prion diseases of humans (e.g., Creutzfeldt-Jakob disease) and animals (e.g., scrapie in sheep, chronic wasting disease
Andreu Matamoros-Angles, Behnam Mohammadi, Feizhi Song, Mohsin Shafiq, Santra Brenna, Berta Puig, Markus Glatzel, Hermann C Altmeppen   +7 more
doaj   +1 more source

PrPC as a Transducer of Physiological and Pathological Signals

Frontiers in Molecular Neuroscience, 2021
After the discovery of prion phenomenon, the physiological role of the cellular prion protein (PrPC) remained elusive. In the past decades, molecular and cellular analysis has shed some light regarding interactions and functions of PrPC in health and ...
Jessica D. Panes, Paulina Saavedra, Paulina Saavedra, Benjamin Pineda, Kathleen Escobar, Kathleen Escobar, Magdalena E. Cuevas, Gustavo Moraga-Cid, Jorge Fuentealba, Coralia I. Rivas, Human Rezaei, Human Rezaei, Human Rezaei, Carola Muñoz-Montesino   +13 more
doaj   +1 more source

Treatment of microglia with Anti-PrP monoclonal antibodies induces neuronal apoptosis in vitro

Heliyon, 2021
Previous reports highlighted the neurotoxic effects caused by some motif-specific anti-PrPC antibodies in vivo and in vitro. In the current study, we investigated the detailed alterations of the proteome with liquid chromatography–mass spectrometry ...
Utpal Kumar Adhikari, Elif Sakiz, Umma Habiba, Meena Mikhael, Matteo Senesi, Monique Antoinette David, Gilles J. Guillemin, Lezanne Ooi, Tim Karl, Steven Collins, Mourad Tayebi   +10 more
doaj   +1 more source