Results 11 to 20 of about 1,553,593 (211)

Exploration of the main sites for the transformation of normal prion protein (PrPC) into pathogenic prion protein (PrPsc)

Journal of Veterinary Research, 2017
Introduction: The functions and mechanisms of prion proteins (PrPC) are currently unknown, but most experts believe that deformed or pathogenic prion proteins (PrPSc) originate from PrPC, and that there may be plural main sites for the conversion of ...
Liu Xi-Lin, Feng Xiao-Li, Wang Guang-Ming, Gong Bin-Bin, Ahmad Waqas, Liu Nan-Nan, Zhang Yuan-Yuan, Yang Li, Ren Hong-Lin, Cui Shu-Sen   +9 more
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Cellular Prion Protein (PrPC): Identification and Characterization of Novel Interacting Partners [PDF]

, 2011
The cellular prion protein (PrPC) is highly conserved throughout the evolution of mammals. (What does this sentence mean? What do you mean by ``conserved´´? This protein was higly conserved during the evolution
Zafar, Saima
core   +4 more sources

PrPC has nucleic acid chaperoning properties similar to the nucleocapsid protein of HIV-1.

, 2002
International audienceThe function of the cellular prion protein (PrPC) remains obscure. Studies suggest that PrPC functions in several processes including signal transduction and Cu2+ metabolism.
Gabus, Caroline, Dormont, Dominique, Swietnicki, Wieslaw, Leblanc, Pascal, Nandi, Pradip, Marck, Daniel, Grave, Linda, Derrington, Edmund, A., Chnaidermann, Jonas, Morillas, Manuel, Darlix, Jean-Luc   +10 more
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The Cellular Prion Protein—ROCK Connection: Contribution to Neuronal Homeostasis and Neurodegenerative Diseases

Frontiers in Cellular Neuroscience, 2021
Amyloid-based neurodegenerative diseases such as prion, Alzheimer's, and Parkinson's diseases have distinct etiologies and clinical manifestations, but they share common pathological events.
Benoit Schneider, Benoit Schneider, Anne Baudry, Anne Baudry, Mathéa Pietri, Mathéa Pietri, Aurélie Alleaume-Butaux, Aurélie Alleaume-Butaux, Aurélie Alleaume-Butaux, Chloé Bizingre, Chloé Bizingre, Pierre Nioche, Pierre Nioche, Pierre Nioche, Odile Kellermann, Odile Kellermann, Jean-Marie Launay, Jean-Marie Launay   +17 more
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Cellular prion protein (PrPC) in the development of Merlin-deficient tumours [PDF]

Oncogene, 2017
Loss of function mutations in the neurofibromatosis Type 2 (NF2) gene, coding for a tumour suppressor, Merlin, cause multiple tumours of the nervous system such as schwannomas, meningiomas and ependymomas. These tumours may occur sporadically or as part of the hereditary condition neurofibromatosis Type 2 (NF2). Current treatment is confined to (radio)
Provenzano, L, Ryan, Y, Hilton, DA, Lyons-Rimmer, J, Dave, F, Maze, EA, Adams, CL, Rigby-Jones, R, Ammoun, S, Hanemann, CO   +9 more
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Cellular Prion Protein (PrPc): Putative Interacting Partners and Consequences of the Interaction [PDF]

International Journal of Molecular Sciences, 2020
Cellular prion protein (PrPc) is a small glycosylphosphatidylinositol (GPI) anchored protein most abundantly found in the outer leaflet of the plasma membrane (PM) in the central nervous system (CNS). PrPc misfolding causes neurodegenerative prion diseases in the CNS.
Hajar Miranzadeh Mahabadi, Changiz Taghibiglou   +1 more
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Prion protein PrPc interacts with molecular chaperones of the Hsp60 family [PDF]

Journal of Virology, 1996
Prions mediate the pathogenesis of certain neurodegenerative diseases, including bovine spongiform encephalopathy in cattle and Creutzfeldt-Jakob disease in humans. The prion particle consists mainly, if not entirely, of PrPSc, a posttranslationally modified isoform of the cellular host-encoded prion protein (PrPc).
F, Edenhofer, R, Rieger, M, Famulok, W, Wendler, S, Weiss, E L, Winnacker   +5 more
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The Multifaceted Functions of Prion Protein (PrPC) in Cancer

Cancers, 2023
The cellular prion protein (PrPC) is a glycoprotein anchored to the cell surface by glycosylphosphatidylinositol (GPI). PrPC is expressed both in the brain and in peripheral tissues. Investigations on PrPC’s functions revealed its direct involvement in neurodegenerative and prion diseases, as well as in various physiological processes such as anti ...
Roland Abi Nahed, Hasan Safwan-Zaiter, Kevin Gemy, Camille Lyko, Mélanie Boudaud, Morgane Desseux, Christel Marquette, Tiphaine Barjat, Nadia Alfaidy, Mohamed Benharouga   +9 more
openaire   +4 more sources

Cross-Linking Cellular Prion Protein Induces Neuronal Type 2-Like Hypersensitivity

Frontiers in Immunology, 2021
BackgroundPrevious reports identified proteins associated with ‘apoptosis’ following cross-linking PrPC with motif-specific anti-PrP antibodies in vivo and in vitro.
Utpal Kumar Adhikari, Elif Sakiz, Xian Zhou, Umma Habiba, Sachin Kumar, Meena Mikhael, Matteo Senesi, Matteo Senesi, Chun Guang Li, Gilles J. Guillemin, Lezanne Ooi, Lezanne Ooi, Monique Antoinette David, Steven Collins, Steven Collins, Tim Karl, Tim Karl, Tim Karl, Mourad Tayebi   +18 more
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Autophagy Activation Associates with Suppression of Prion Protein and Improved Mitochondrial Status in Glioblastoma Cells

Cells, 2023
Cells from glioblastoma multiforme (GBM) feature up-regulation of the mechanistic Target of Rapamycin (mTOR), which brings deleterious effects on malignancy and disease course.
Paola Lenzi, Carla L. Busceti, Gloria Lazzeri, Rosangela Ferese, Francesca Biagioni, Alessandra Salvetti, Elena Pompili, Valerio De Franchis, Stefano Puglisi-Allegra, Alessandro Frati, Michela Ferrucci, Francesco Fornai   +11 more
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