Results 41 to 50 of about 1,553,593 (211)

Regulation of focal adhesion formation and filopodia extension by the cellular prion protein (PrPC) [PDF]

FEBS Letters, 2008
While the prion protein (PrP) is clearly involved in neuropathology, its physiological roles remain elusive. Here, we demonstrate PrP functions in cell–substrate interaction in Drosophila S2, N2a and HeLa cells.
Schrock, Yvonne, Solis Padilla, Gonzalo, Stürmer, Claudia   +2 more
openaire   +3 more sources

Post-translational modifications in prion diseases

Frontiers in Molecular Neuroscience
More than 650 reversible and irreversible post-translational modifications (PTMs) of proteins have been listed so far. Canonical PTMs of proteins consist of the covalent addition of functional or chemical groups on target backbone amino-acids or the ...
Chloé Bizingre, Chloé Bizingre, Clara Bianchi, Clara Bianchi, Anne Baudry, Anne Baudry, Aurélie Alleaume-Butaux, Aurélie Alleaume-Butaux, Benoit Schneider, Benoit Schneider, Benoit Schneider, Mathéa Pietri, Mathéa Pietri   +12 more
doaj   +1 more source

Synaptic Dysfunction in Prion Diseases: A Trafficking Problem?

International Journal of Cell Biology, 2013
Synaptic dysfunction is an important cause of neurological symptoms in prion diseases, a class of clinically heterogeneous neurodegenerative disorders caused by misfolding of the cellular prion protein (PrPC).
Assunta Senatore, Elena Restelli, Roberto Chiesa   +2 more
doaj   +1 more source

An antipsychotic drug exerts anti-prion effects by altering the localization of the cellular prion protein.

PLoS ONE, 2017
Prion diseases are neurodegenerative conditions characterized by the conformational conversion of the cellular prion protein (PrPC), an endogenous membrane glycoprotein of uncertain function, into PrPSc, a pathological isoform that replicates by imposing
Claudia Stincardini, Tania Massignan, Silvia Biggi, Saioa R Elezgarai, Valeria Sangiovanni, Ilaria Vanni, Michael Pancher, Valentina Adami, Jorge Moreno, Matteo Stravalaci, Giulia Maietta, Marco Gobbi, Alessandro Negro, Jesús R Requena, Joaquín Castilla, Romolo Nonno, Emiliano Biasini   +16 more
doaj   +1 more source

The cellular prion protein interacts with and promotes the activity of Na,K-ATPases.

PLoS ONE, 2021
The prion protein (PrP) is best known for its ability to cause fatal neurodegenerative diseases in humans and animals. Here, we revisited its molecular environment in the brain using a well-developed affinity-capture mass spectrometry workflow that ...
Declan Williams, Mohadeseh Mehrabian, Hamza Arshad, Shehab Eid, Christopher Sackmann, Wenda Zhao, Xinzhu Wang, Farinaz Ghodrati, Claire E Verkuyl, Joel C Watts, Gerold Schmitt-Ulms   +10 more
doaj   +1 more source

Prion therapeutics: Lessons from the past

Prion, 2022
Prion diseases are a group of incurable zoonotic neurodegenerative diseases (NDDs) in humans and other animals caused by the prion proteins. The abnormal folding and aggregation of the soluble cellular prion proteins (PrPC) into scrapie isoform (PrPSc ...
Kyu Hwan Shim, Niti Sharma, Seong Soo A An   +2 more
doaj   +1 more source

Genome‐scale insights into metabolic streamlining and photosynthetic energy balance in the extremophile green alga Picocystis salinarum (Picocystophyceae, Chlorophyta)

Journal of Phycology, EarlyView.
Abstract Picocystis salinarum is an early‐diverging chlorophyte and the sole described member of the Picocystophyceae, frequently dominating hypersaline and alkaline lakes despite extreme physicochemical constraints. To elucidate the genomic foundations of its ecological success, we generated a fully annotated, chromosome‐scale nuclear genome assembly ...
Claude Lemieux, Christian Otis, Monique Turmel   +2 more
wiley   +1 more source

Die Rolle von PrPC in der neuronalen Differenzierung und die Ausbreitung der infektiösen Isoform PrPSc durch Mikrovesikel [PDF]

, 2008
Prion diseases or transmissible spongiform encephalopathies (TSEs) are rare neurological disorders that may be of genetic or infectious origin, but most frequently occur sporadically in humans. Their outcome is invariably fatal.
Barenco Montrasio, Maria Grazia
core  

Prominent Stress Response of Purkinje Cells in Creutzfeldt–Jakob Disease

Neurobiology of Disease, 2001
To examine the role of stress-related 70-kDa heat shock proteins (Hsp-s) in Creutzfeldt–Jakob disease (CJD), we performed immunocytochemistry to detect Hsp-72 and Hsp-73, together with the abnormal (PrPSc) and the presumed cellular form (PrPC) of the ...
Gábor G. Kovács, István Kurucz, Herbert Budka, Csaba Ádori, Ferenc Müller, Péter Ács, Stefan Klöppel, Hermann M. Schätzl, R.John Mayer, Lajos László   +9 more
doaj   +1 more source

Papel da proteína prion celular (PrPC) em alterações comportamentais e neuroquímicas associadas ao envelhecimento em camundongo [PDF]

, 2009
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Farmacologia, Florianópolis, 2009.A proteína prion celular (PrPC) é uma glicoproteína ancorada aos neurônios que tem sido ...
Rial, Daniel
core