Common themes in PrP signaling: the Src remains the same
Frontiers in Cell and Developmental Biology, 2014 The ability of the cellular prion protein (PrPC) to trigger intracellular signals appears central to neurodegeneration pathways, yet the physiological significance of such signals is rather puzzling.
Katharina eOchs +2 more
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Alterations in the brain interactome of the intrinsically disordered N-terminal domain of the cellular prion protein (PrPC) in Alzheimer's disease. [PDF]
PLoS ONE, 2018 The cellular prion protein (PrPC) is implicated in neuroprotective signaling and neurotoxic pathways in both prion diseases and Alzheimer's disease (AD). Specifically, the intrinsically disordered N-terminal domain (N-PrP) has been shown to interact with
Sarah Ulbrich +9 more
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Brain and Behavior, Volume 16, Issue 8, August 2026.Neurodegenerative diseases share common pathological mechanisms including chronic neuroinflammation, oxidative stress, mitochondrial dysfunction, and protein aggregation. Despite distinct hallmarks in Alzheimer's, Parkinson's, Huntington's, ALS, and MS, these processes converge, driving progressive neuronal damage and neurodegeneration.
Fatemeh sadat Aldaghi +4 more
wiley +1 more source
ACAT1, Cav-1, and PrP expression in brains and skin fibroblasts from Sarda breed sheep with scrapie-resistant and scrapie-susceptible genotype. [PDF]
, 2007 Scrapie is an infective ovine neurodegenerative disease; the only identified component of the infectious agent being an aberrant isoform (PrPSc) of the cellular prion protein (PrPC). So far, no means for ante-mortem diagnosis are available for Scrapie as
Claudia Abete +9 more
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A receptor for infectious and cellular prion protein
Brazilian Journal of Medical and Biological Research, 1999 Prions are an unconventional form of infectious agents composed only of protein and involved in transmissible spongiform encephalopathies in humans and animals.
V.R. Martins
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Glucose Transporter 1 in Health and Disease
MedComm, Volume 7, Issue 8, August 2026.As the quintessential facilitator of basal glucose uptake, glucose transporter 1 (GLUT1) is indispensable for maintaining systemic energy homeostasis. This graphical abstract delineates the multidimensional landscape of GLUT1 in normal physiology. It highlights its tissue‐specific metabolic roles—from fueling erythrocytes and fetal development to ...
Yi Tai +3 more
wiley +1 more source
Análise da influência da proteína príon celular (PrPc) e de seu ligante, a fosfoproteína induzida por estresse do tipo 1 (STI1), na diferenciação das células-tronco da crista neural truncal, in vitro [PDF]
, 2009 TCC(graduação) - Universidade Federal de Santa Catarina. Centro de Ciências Biológicas. Biologia.A crista neural (CN) é uma estrutura embrionária capaz de originar grande variedade de tipos celulares, incluindo neurônios e células gliais do sistema ...
Schmitt, Suelen dos Santos
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Exploring the mechanisms involved in prion degradation and spreading from cell-to-cell in neuronal cell models [PDF]
, 2011 Transmissible spongiform encephalopathies (TSE), also known as prion diseases, are fatal neurodegenerative disorders present both in human and animals with different aetiology as they can occur genetically, spontaneously or by infection (Prusiner 1998 ...
Marzo, Ludovica
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α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates
FEBS Letters, Volume 600, Issue 14, Page 1955-1965, July 2026.Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino +2 more
wiley +1 more source
Efeito da proteina celular do Prion (PrPc) na atividade da enzima superóxido dismutase (SOD) em células vasculares sob estresse oxidativo [PDF]
, 2008 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Programa de Pós-graduação em FarmáciaA proteína celular do prion (PrPC) é expressa em vários tipos celulares, especialmente em neurônios. Sua função fisiológica
Soprana, Hélen Zocche
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