Results 71 to 80 of about 1,553,593 (211)
Cellular Prion Protein: From Physiology to Pathology
Viruses, 2012 The human cellular prion protein (PrPC) is a glycosylphosphatidylinositol (GPI) anchored membrane glycoprotein with two N-glycosylation sites at residues 181 and 197. This protein migrates in several bands by Western blot analysis (WB).
Yutaka Kikuchi +3 more
doaj +1 more source
The Effects of Ca2+ Concentration and E200K Mutation on the Aggregation Propensity of PrPC: A Computational Study. [PDF]
PLoS ONE, 2016 The propensity of cellular prion protein to aggregation is reputed essential for the initiation of the amyloid cascade that ultimately lead to the accumulation of neurotoxic aggregates.
Alessandro Marrone +2 more
doaj +1 more source
Journal of Pineal Research, Volume 78, Issue 4, July 2026.ABSTRACT Oncogenic condensates act as biophysical sanctuaries that stabilize malignant survival programs. However, a universal regulator capable of orchestrating the integrated biophysical axes governing cellular phase behavior has remained elusive.
Doris Loh +3 more
wiley +1 more source
Monomeric amyloid-β reduced amyloid-β oligomer-induced synapse damage in neuronal cultures
Neurobiology of Disease, 2018 Alzheimer's disease is a progressive neurodegenerative disease characterized by the accumulation of amyloid-β (Aβ) in the brain. Aβ oligomers are believed to cause synapse damage resulting in the memory deficits that are characteristic of this disease ...
Clive Bate, Alun Williams
doaj +1 more source
CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.NBP counteracts PrP106‐126‐induced neurotoxicity by activating NRF2 and restoring OPA1/DRP1‐mediated mitochondrial dynamics. It suppresses oxidative stress and preserves mitochondrial function and bioenergetics. These actions support NBP as a promising therapeutic candidate for prion‐related neurodegeneration.
Wei Wu +3 more
wiley +1 more source
Molecular Oncology, 2019 Epidermal growth factor receptor (EGFR) supports colorectal cancer progression via oncogenic signaling. Anti‐EGFR therapy is being investigated as a clinical option for colorectal cancer, and an observed interaction between EGFR and Prion protein has ...
Caroline J. Atkinson +9 more
doaj +1 more source
Cellular prion protein and γ-synuclein overexpression in LS 174T colorectal cancer cell drives endothelial proliferation-to-differentiation switch [PDF]
PeerJ, 2018 Background Tumor-induced angiogenesis is an imperative event in pledging new vasculature for tumor metastasis. Since overexpression of neuronal proteins gamma-synuclein (γ-Syn) and cellular prion protein (PrPC) is always detected in advanced stages of ...
Sing-Hui Ong +3 more
doaj +2 more sources
Doppel and PrPC do not share the same membrane microenvironment [PDF]
, 2002 Doppel is a paralog of the normal prion protein, PrPC. It has been suggested that Doppel can compensate for the absence of PrPC in PrP0/0 mice. In this work, we tested whether Doppel and PrPC share the same cell location, thereby sharing the same ...
Ruth Gabizon +5 more
core +1 more source
Frontiers in Neuroscience, 2019 The recent recognition that Alzheimer disease-like pathology may be found in chronic traumatic encephalopathy (CTE) even after acute mild traumatic brain injury (mTBI) has increased the urgency of elucidating mechanisms, identifying biomarkers predictive
Edward J. Goetzl +6 more
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Understanding the Phenotypic Heterogeneity Within the Sporadic Creutzfeldt–Jakob Disease MV1 Subtype
Neuropathology and Applied Neurobiology, Volume 52, Issue 3, June 2026.We present the clinical, pathological and prion biophysical features of three atypical cases of the MV1 subtype of sporadic Creutzfeldt–Jakob disease (sCJD). We propose that these heterozygous cases exist on a spectrum ranging from MM1‐like to VV1‐like phenotypes and recommend that subtyping be performed at pH 6.9 to avoid missing atypical or mixed ...
Satish K. Nemani +6 more
wiley +1 more source