Results 91 to 100 of about 1,553,593 (211)
Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.Abstract Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by β‐amyloid deposition, hyperphosphorylated tau protein, and progressive neuronal loss. Mitochondria form a dynamic interconnected network within the central nervous system, and their dysfunction plays a central role in AD, involving oxidative stress, kinetic ...
Liping Xing +7 more
wiley +1 more source
The Phenotypic Spectrum of Sporadic Creutzfeldt‐Jakob Disease Cortical Subtype
Annals of Neurology, Volume 99, Issue 4, Page 883-896, April 2026.Objective The objective of this study was to characterize the phenotypic spectrum of the rare sporadic Creutzfeldt‐Jakob disease cortical subtype (sCJDMM/MV2C) in a large multicentric autopsy cohort. Methods We evaluated clinical histories, biofluid markers, brain diffusion‐weighted (DW)‐magnetic resonance imaging (MRI), and electroencephalogram (EEG ...
Simone Baiardi +16 more
wiley +1 more source
New light on prions: putative role of co-operation of PrPc and Aβ proteins in cognition
Folia Neuropathologica, 2014 A seminal article of Takahashi et al. reporting concomitant accumulation of cellular prion protein (PrPc) and β-amyloid (Aβ) in dystrophic neurites, within neuritic plaques raised an exciting issue that is important for our understanding of mechanisms of neurodegeneration.
Adrian Andrzej, Chrobak, Dariusz, Adamek
openaire +2 more sources
The GPCR Connection: Linking Alzheimer's Disease and Glioblastoma
Journal of Cellular and Molecular Medicine, Volume 30, Issue 7, April 2026.ABSTRACT Alzheimer's disease (AD) and glioblastoma multiforme (GBM) are biologically distinct age‐related brain disorders with opposing clinical phenotypes. AD is characterised by progressive neurodegeneration and cognitive decline, whereas GBM is characterised by aggressive cellular proliferation and a poor prognosis.
Ana B. Caniceiro +4 more
wiley +1 more source
Characterization of cellular prion protein (PrPC) in Caenorhabditis elegans
, 2011 Cellular prion protein (PrPC) is a conserved glycoprotein predominantly expressed in neurons, glial and lymphatic cells. It is associated with the broad group of prion diseases in which PrPC becomes misfolded. However, the purpose of PrPC in living cells is still enigmatic.
openaire +2 more sources
PLoS ONE, 2020 Chronic wasting disease is a transmissible spongiform encephalopathy of cervids. This fatal neurodegenerative disease is caused by misfolding of the cellular prion protein (PrPC) to pathogenic conformers (PrPSc), and the pathogenic forms accumulate in ...
Soyoun Hwang +2 more
doaj +1 more source
mSphere, 2017 Substantial evidence supports the hypothesis that prions are misfolded, infectious, insoluble, and protease-resistant proteins (PrPRES) devoid of instructional nucleic acid that cause transmissible spongiform encephalopathies (TSEs).
Crystal Meyerett-Reid +5 more
doaj +1 more source
Aspects of prion protein dynamics in cell culture models. [PDF]
, 2005 The cell biology of Prion formation and transfer is not well understood. In order to further elucidate the dynamics of PrPc and PrPsc in a cellular context, fusions between Green Fluorescent Protein (GFP) and PrP were constructed and infected/uninfected ...
Landy, Timothy Adam, Landy, T.A.
core
Microbial Cell Factories, 2017 Background The infectious prion protein (PrPSc or prion) is derived from its cellular form (PrPC) through a conformational transition in animal and human prion diseases.
Romany Abskharon +14 more
doaj +1 more source
PrPC epitopes and toxicity of anti-PrPC antibodies.
, 2016 PrPC epitopes and toxicity of anti-PrPC antibodies.
Regina R. Reimann (695279) +6 more
core +1 more source