Results 111 to 120 of about 1,553,593 (211)
, 2014 Chronic wasting disease (CWD) is a transmissible spongiform encephalopathy that is endemic to the Southern Wyoming/Northern Colorado area. In a previous study, we produced monoclonal antibodies against synthetic peptide sequences representing PrPc 225F ...
Kaitlin McDaniel (10081273)
core +1 more source
Function of PrPC as a copper-binding protein at the synapse
, 2000 The prion protein (PrPC) shows cooperative copper binding of the N-terminal octarepeat (PHGGGWGO) x4. In brain homogenates, PrPC is found in highest concentration in synaptosomal fractions.
Madlung, A. +4 more
core +2 more sources
Role of PrPC and STI1/HOP in human glioblastoma stem cells biology in vivo.
, 2018 O GBM é o tipo mais agressivo de glioma, apresentando células indiferenciadas (CTGs), responsáveis pela proliferação, invasão e recidiva tumoral. Avaliamos o papel da proteína PrPC e seu ligante HOP na proliferação e autorrenovação de CTGs.
Iglesia, Rebeca Piatniczka
core +1 more source
Folding and fibril formation of prions [PDF]
Prions diseases are a group of fatal neurodegenerative disorders called the transmissible spongiform encephalopathies (TSEs), which include bovine spongiform encephalopathy in cattle, scrapie in sheep and Creutzfeldt-Jakob disease (CJD) in humans ...
Gierusz, Leszek A.
core
The immunobiology of PrPc protein
, 2006 Phenotypic studies of mice with altered levels of PrPc expression showed differences in lymphocyte subset composition of peripheral lymphoid tissue.
Greenwood, G R
core
Role of PrPC in tau protein levels and phosphorylation in Alzheimer's disease evolution
, 2014 Alzheimer's disease (AD) is characterized by the presence of amyloid plaques mainly consisting of hydrophobic -amyloid peptide (A) aggregates and neurofibrillary tangles (NFTs) composed principally of hyperphosphorylated tau. A oligomers have been described as the earliest effectors to negatively affect synaptic structure and plasticity in the affected
Vergara, C. +5 more
openaire +1 more source
The protein disulfide isomerase P4HB/PDIA1 modulates cellular and misfolded forms of the prion protein. [PDF]
PLoS PathogAmano G +4 more
europepmc +1 more source
Isotope-edited ESEEM: A new method for probing copper binding sites in neurodegenerative proteins. [PDF]
J Biol ChemMillhauser GL +3 more
europepmc +1 more source
Proteins as markers of TSE infection in sheep blood
, 2008 Transmissible spongiform encephalopathies (TSEs) are a group of fatal infectious neurodegenerative diseases affecting both humans and agricultural animals. TSE transmission via blood transfusion has been demonstrated experimentally in rodent, primate and
Martin, Joanne
core